Effect of 1,1,1-trichloroethane on calcium current of rat dorsal root ganglion neurons

Dorsal root ganglion neurons were obtained from newborn rats, and the voltage-operated calcium channels were isolated. The effect of 1,1,1-trichloroethane on Ca current was then examined. Results showed that the inhibitory effects of trichloroethane were different for the low-voltage-activated curre...

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Veröffentlicht in:	Bulletin of environmental contamination and toxicology 2001-10, Vol.67 (4), p.476-482
Hauptverfasser:	OKUDA, M, KUNITSUGU, I, KOBAYAKAWA, S, HOBARA, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium Channels - drug effects Calcium Channels - physiology Chemical and industrial products toxicology. Toxic occupational diseases Ganglia, Spinal - drug effects Ganglia, Spinal - physiology Ion Exchange Medical sciences Patch-Clamp Techniques Rats Solvents Toxicology Trichloroethanes - adverse effects
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Zusammenfassung:	Dorsal root ganglion neurons were obtained from newborn rats, and the voltage-operated calcium channels were isolated. The effect of 1,1,1-trichloroethane on Ca current was then examined. Results showed that the inhibitory effects of trichloroethane were different for the low-voltage-activated current and the high-voltage-activated current. While trichloroethane inhibited both channels, the concentration-inhibition curves differed. Recovery from inhibition took longer than the appearance of inhibition.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/s001280148