Adverse effects of high dose aspirin on platelet adhesion to experimental autogenous vein grafts

Prostacyclin (PGI2) production and platelet adhesion were studied in veins grafted into the arterial system of rabbits. Animal groups consisted of: no treatment; low dose aspirin (ASA) (0.5 mg·kg−1·24 h−1) plus dipyridamole (2 mg·kg−1·6 h−1); high dose ASA (40 mg·kg−1·24 h−1) plus dipyridamole (2 mg...

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Veröffentlicht in:	Cardiovascular research 1985-12, Vol.19 (12), p.770-776
Hauptverfasser:	GERSHLICK, ANTHONY H, COURT, Y DENISE SYNDERCOMBE, MURDAY, ANDREW J, LEWIS, C TERENCE, MILLS, PETER G
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - biosynthesis Animals aspirin Aspirin - adverse effects Aspirin - pharmacology Autoradiography Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Carotid Arteries - metabolism dipyndamole Dipyridamole - adverse effects Dipyridamole - pharmacology Epoprostenol - biosynthesis Graft Occlusion, Vascular - chemically induced Graft Occlusion, Vascular - physiopathology Jugular Veins - metabolism Jugular Veins - transplantation Medical sciences Models, Biological Pharmacology. Drug treatments Platelet Adhesiveness - drug effects platelet deposition prostacyclin (PCI2) Rabbits vein grafts
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Zusammenfassung:	Prostacyclin (PGI2) production and platelet adhesion were studied in veins grafted into the arterial system of rabbits. Animal groups consisted of: no treatment; low dose aspirin (ASA) (0.5 mg·kg−1·24 h−1) plus dipyridamole (2 mg·kg−1·6 h−1); high dose ASA (40 mg·kg−1·24 h−1) plus dipyridamole (2 mg·kg−1·6 h−1); dipyridamole (2 mg·kg−1·6 h1) alone. Results showed that vein grafts from animals treated with high dose ASA plus dipyridamole produced significantly less PGI2 than the other three groups (p
ISSN:	0008-6363 1755-3245
DOI:	10.1093/cvr/19.12.770