Growth and rosmarinic acid production in cell suspension cultures of Salvia officinalis L

Rosmarinic acid (RA) is a natural antioxidant produced by cell suspension cultures of sage (Salvia officinalis L.). The growth and production of RA by these cells can be modified by the type of culture medium. Production can be increased 10-fold to attain 6.4 g.l-1 under optimal conditions. Investig...

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Veröffentlicht in:	Plant cell reports 1992-04, Vol.11 (3), p.109-112
Hauptverfasser:	Hippolyte, I, Marin, B, Baccou, J.C, Jonard, R
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidants Biological and medical sciences Biotechnology cell growth cell suspension culture crop production culture media Establishment of new cell lines, improvement of cultural methods, mass culture Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies phenylalanine Plant cells and fungal cells Salvia officinalis sucrose
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Zusammenfassung:	Rosmarinic acid (RA) is a natural antioxidant produced by cell suspension cultures of sage (Salvia officinalis L.). The growth and production of RA by these cells can be modified by the type of culture medium. Production can be increased 10-fold to attain 6.4 g.l-1 under optimal conditions. Investigation of kinetics showed that a change in the medium caused shifts in peaks of growth and production, and modifications of the cell metabolism. RA production can be correlated with growth or begins only when growth has stopped.
ISSN:	0721-7714 1432-203X
DOI:	10.1007/BF00232160