Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium

Thymine and cytosine as well as the intermediates in pyrimidine biosynthetic pathway dihydroorotic acid, orotic acid, carbamyl aspartate and 5'-uridine monophosphate and folic acid, was synergistic. 2-14C-Thymine, 6-14C-orotic acid and 14C-formate but not 2-14C-uracil, were incorporated into DN...

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Veröffentlicht in:	Folia microbiologica 1986-01, Vol.31 (4), p.272-276
Hauptverfasser:	VISHWANATH, P, BASAPPA, S. C, SREENIVASA MURTHY, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Action of physical and chemical agents on bacteria Aflatoxin B1 Aflatoxins - antagonists & inhibitors Aflatoxins - pharmacology Aminopterin - pharmacology Aspartic Acid - pharmacology Bacillus megaterium Bacillus megaterium - drug effects Bacillus megaterium - genetics Bacillus megaterium - metabolism Bacteriology Biological and medical sciences DNA, Bacterial - metabolism Drug Synergism Folic Acid - metabolism Folic Acid - pharmacology Fundamental and applied biological sciences. Psychology Microbiology Orotic Acid - metabolism Orotic Acid - pharmacology Thymine - metabolism Thymine - pharmacology Uracil - metabolism Uracil - pharmacology Uridine Monophosphate - pharmacology
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Zusammenfassung:	Thymine and cytosine as well as the intermediates in pyrimidine biosynthetic pathway dihydroorotic acid, orotic acid, carbamyl aspartate and 5'-uridine monophosphate and folic acid, was synergistic. 2-14C-Thymine, 6-14C-orotic acid and 14C-formate but not 2-14C-uracil, were incorporated into DNA more in the presence of aflatoxin. These findings indicated that aflatoxin inhibited the pyrimidine base synthesis which could be overcome to a great extent by the addition of thymine and folic acid to aflatoxin-treated cells.
ISSN:	0015-5632 1874-9356
DOI:	10.1007/BF02926950