ASBESTOS-RELATED PLEURAL THICKENING IS INDEPENDENTLY ASSOCIATED WITH LOWER LEVELS OF LUNG FUNCTION AND WITH SHORTNESS OF BREATH

This study investigated the relative contribution of asbestos-related pleural thickening (PT) to lung function indices and to respiratory symptoms. A group of 828 former asbestos cement workers enrolled in a cross-sectional and cohort study of respiratory morbidity and submitted to a detailed occupational history, respiratory symptoms questionnaire, spirometry, postero-anterior chest x-ray, and high-resolution computed chest tomography (HRCT). Asbestos exposure was assessed by years of exposure (a semi-quantitative method), cumulative exposure, and latency time from first exposure. Smoking was assessed in pack-years. PT and asbestosis were assessed according to HRCT criteria. Statistical analysis included descriptive analysis, univariate and multivariate analysis of variance for comparisons of factors related to PT, stepwise multiple regression analysis for continuous dependent variables, and logistic regression analysis for dichotomous dependent variables. Mean age was 51.4 (SD 10.5) years, mean years of exposure 12.4 (SD 8.8), mean cumulative exposure 79.9 (SD 68.5), and mean latency time 25.2 yr (SD 10.4). Of the 828, 238 (28.7%) were smokers, 288 (34.8%) former smokers, and 302 (36.2%) nonsmokers. PT was present in 246 (29.7%) and asbestosis in 74 (8.9%); 97 (11.9%) had shortness of breath of Grade III or more. PT subjects had lower height-adjusted forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) and lower FEV1/FVC% (p < .00001 for all). Variables significantly related to PT were age (p < .0001), years of exposure (p < .00001), cumulative exposure (p < .00001), latency time (p < .00001), pack-years (p < .00001), and asbestosis (p < .001). In a multiple stepwise regression model, after controlling for confounders, heightadjusted FEV1 and FVC were inversely and significantly associated with PT, mainly when associated with asbestosis. A logistic regression model with shortness of breath as the dependent variable, controlled for confounders, showed that PT was significantly associated with the symptom, even without asbestosis. In conclusion, PT is independently associated with lower values of FEV1 and FVC. PT is also independently associated with an increased risk of shortness of breath report. PT should be considered as a disease for clinical follow-up and for compensation claims.