Early effects of vitamin D metabolites on phosphate fluxes in isolated rat enterocytes
The present studies were designed to explore the possibility that, in addition to its well-known steroidlike action, 1,25-dihydroxyvitamin D3 (1,25(OH) sub(2)D sub(3)), the active vitamin D sub(3) metabolite, modulates inorganic phosphate (P sub(i)) transport across the intestinal mucosa through mor...
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| Veröffentlicht in: | American Journal of Physiology: Cell Physiology 1985-01, Vol.248 (1), p.G40-G45 |
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| container_end_page | G45 |
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| container_issue | 1 |
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| container_title | American Journal of Physiology: Cell Physiology |
| container_volume | 248 |
| creator | Karsenty, G Lacour, B Ulmann, A Pierandrei, E Drueeke, T |
| description | The present studies were designed to explore the possibility that, in addition to its well-known steroidlike action, 1,25-dihydroxyvitamin D3 (1,25(OH) sub(2)D sub(3)), the active vitamin D sub(3) metabolite, modulates inorganic phosphate (P sub(i)) transport across the intestinal mucosa through more rapid membrane effects. Enterocytes were mechanically isolated from the duodenojejunum of vitamin D-replete rats. In this model enterocyte P sub(i) uptake was a temperature-dependent as well as a Na super(+)-dependent process. In vitro addition of 1,25(OH) sub(2)D sub(3) (1 pM) led to a significant increase in Na super(+)-dependent initial P sub(i) uptake velocity (iV sub(Pi)) within 20 min. |
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Enterocytes were mechanically isolated from the duodenojejunum of vitamin D-replete rats. In this model enterocyte P sub(i) uptake was a temperature-dependent as well as a Na super(+)-dependent process. In vitro addition of 1,25(OH) sub(2)D sub(3) (1 pM) led to a significant increase in Na super(+)-dependent initial P sub(i) uptake velocity (iV sub(Pi)) within 20 min.</description><identifier>ISSN: 0363-6143</identifier><language>eng</language><subject>1,25-dihydroxycholecalciferol ; enterocytes ; membrane structure ; phosphate ; plasma membranes</subject><ispartof>American Journal of Physiology: Cell Physiology, 1985-01, Vol.248 (1), p.G40-G45</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Karsenty, G</creatorcontrib><creatorcontrib>Lacour, B</creatorcontrib><creatorcontrib>Ulmann, A</creatorcontrib><creatorcontrib>Pierandrei, E</creatorcontrib><creatorcontrib>Drueeke, T</creatorcontrib><title>Early effects of vitamin D metabolites on phosphate fluxes in isolated rat enterocytes</title><title>American Journal of Physiology: Cell Physiology</title><description>The present studies were designed to explore the possibility that, in addition to its well-known steroidlike action, 1,25-dihydroxyvitamin D3 (1,25(OH) sub(2)D sub(3)), the active vitamin D sub(3) metabolite, modulates inorganic phosphate (P sub(i)) transport across the intestinal mucosa through more rapid membrane effects. Enterocytes were mechanically isolated from the duodenojejunum of vitamin D-replete rats. In this model enterocyte P sub(i) uptake was a temperature-dependent as well as a Na super(+)-dependent process. In vitro addition of 1,25(OH) sub(2)D sub(3) (1 pM) led to a significant increase in Na super(+)-dependent initial P sub(i) uptake velocity (iV sub(Pi)) within 20 min.</description><subject>1,25-dihydroxycholecalciferol</subject><subject>enterocytes</subject><subject>membrane structure</subject><subject>phosphate</subject><subject>plasma membranes</subject><issn>0363-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNqNyksKwjAUheEMFKyPPdyRs0JjYsCxVlyAOC2x3tBImtTcVOzuzcAFODrwn2_GikooUSouxYItiZ5VVcmdOhTsVuvoJkBjsE0EwcDbJt1bDyfoMel7cDZhPjwMXaCh0wnBuPGTW0aWgsvlAVEnQJ8whnbKfs3mRjvCzW9XbHuur8dLOcTwGpFS01tq0TntMYzUcLmXinMu_oZfcoJEMQ</recordid><startdate>19850101</startdate><enddate>19850101</enddate><creator>Karsenty, G</creator><creator>Lacour, B</creator><creator>Ulmann, A</creator><creator>Pierandrei, E</creator><creator>Drueeke, T</creator><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>19850101</creationdate><title>Early effects of vitamin D metabolites on phosphate fluxes in isolated rat enterocytes</title><author>Karsenty, G ; Lacour, B ; Ulmann, A ; Pierandrei, E ; Drueeke, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_145461113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>1,25-dihydroxycholecalciferol</topic><topic>enterocytes</topic><topic>membrane structure</topic><topic>phosphate</topic><topic>plasma membranes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karsenty, G</creatorcontrib><creatorcontrib>Lacour, B</creatorcontrib><creatorcontrib>Ulmann, A</creatorcontrib><creatorcontrib>Pierandrei, E</creatorcontrib><creatorcontrib>Drueeke, T</creatorcontrib><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>American Journal of Physiology: Cell Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karsenty, G</au><au>Lacour, B</au><au>Ulmann, A</au><au>Pierandrei, E</au><au>Drueeke, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early effects of vitamin D metabolites on phosphate fluxes in isolated rat enterocytes</atitle><jtitle>American Journal of Physiology: Cell Physiology</jtitle><date>1985-01-01</date><risdate>1985</risdate><volume>248</volume><issue>1</issue><spage>G40</spage><epage>G45</epage><pages>G40-G45</pages><issn>0363-6143</issn><abstract>The present studies were designed to explore the possibility that, in addition to its well-known steroidlike action, 1,25-dihydroxyvitamin D3 (1,25(OH) sub(2)D sub(3)), the active vitamin D sub(3) metabolite, modulates inorganic phosphate (P sub(i)) transport across the intestinal mucosa through more rapid membrane effects. Enterocytes were mechanically isolated from the duodenojejunum of vitamin D-replete rats. In this model enterocyte P sub(i) uptake was a temperature-dependent as well as a Na super(+)-dependent process. In vitro addition of 1,25(OH) sub(2)D sub(3) (1 pM) led to a significant increase in Na super(+)-dependent initial P sub(i) uptake velocity (iV sub(Pi)) within 20 min.</abstract></addata></record> |
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| identifier | ISSN: 0363-6143 |
| ispartof | American Journal of Physiology: Cell Physiology, 1985-01, Vol.248 (1), p.G40-G45 |
| issn | 0363-6143 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14546111 |
| source | Alma/SFX Local Collection |
| subjects | 1,25-dihydroxycholecalciferol enterocytes membrane structure phosphate plasma membranes |
| title | Early effects of vitamin D metabolites on phosphate fluxes in isolated rat enterocytes |
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