Early effects of vitamin D metabolites on phosphate fluxes in isolated rat enterocytes

The present studies were designed to explore the possibility that, in addition to its well-known steroidlike action, 1,25-dihydroxyvitamin D3 (1,25(OH) sub(2)D sub(3)), the active vitamin D sub(3) metabolite, modulates inorganic phosphate (P sub(i)) transport across the intestinal mucosa through mor...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1985-01, Vol.248 (1), p.G40-G45
Hauptverfasser: Karsenty, G, Lacour, B, Ulmann, A, Pierandrei, E, Drueeke, T
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Sprache:eng
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Zusammenfassung:The present studies were designed to explore the possibility that, in addition to its well-known steroidlike action, 1,25-dihydroxyvitamin D3 (1,25(OH) sub(2)D sub(3)), the active vitamin D sub(3) metabolite, modulates inorganic phosphate (P sub(i)) transport across the intestinal mucosa through more rapid membrane effects. Enterocytes were mechanically isolated from the duodenojejunum of vitamin D-replete rats. In this model enterocyte P sub(i) uptake was a temperature-dependent as well as a Na super(+)-dependent process. In vitro addition of 1,25(OH) sub(2)D sub(3) (1 pM) led to a significant increase in Na super(+)-dependent initial P sub(i) uptake velocity (iV sub(Pi)) within 20 min.
ISSN:0363-6143