Role of rat liver inducible enzymes in in vitro metabolic transformation of 1-nitropyrene
Liver enzymes (S9) of rats induced with various drugs differently affected the mutagenic response of 1-nitropyrene (1-NP) in vitro. The role of inducible enzymes in 1-NP conversion was evaluated by high-performance liquid chromatography (HPLC) analyses of 1-NP metabolites formed during incubation in...
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| Veröffentlicht in: | Toxicology letters 1986-07, Vol.32 (1), p.89-96 |
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| container_title | Toxicology letters |
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| creator | Belisario, M.A. Carrano, L. de Giulio, A. Buonocore, V. |
| description | Liver enzymes (S9) of rats induced with various drugs differently affected the mutagenic response of 1-nitropyrene (1-NP) in vitro. The role of inducible enzymes in 1-NP conversion was evaluated by high-performance liquid chromatography (HPLC) analyses of 1-NP metabolites formed during incubation in vitro of the chemical with each S9 fraction. Methylcholanthrene (MC)-induced S9 preferentially results in 1-NP hydroxylation in position 6 or 8. Metabolic interconversions among 1-NP metabolites could be inferred from the HPLC patterns. |
| doi_str_mv | 10.1016/0378-4274(86)90053-6 |
| format | Article |
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The role of inducible enzymes in 1-NP conversion was evaluated by high-performance liquid chromatography (HPLC) analyses of 1-NP metabolites formed during incubation in vitro of the chemical with each S9 fraction. Methylcholanthrene (MC)-induced S9 preferentially results in 1-NP hydroxylation in position 6 or 8. Metabolic interconversions among 1-NP metabolites could be inferred from the HPLC patterns.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(86)90053-6</identifier><identifier>PMID: 3738934</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>1-nitropyrene ; Animals ; Biological and medical sciences ; Biotransformation ; Chemical mutagenesis ; Cytochrome P-450 Enzyme System - physiology ; Enzyme Induction ; Hydroxylation ; In Vitro Techniques ; liver ; Liver - enzymology ; Male ; Medical sciences ; MFO-inducers ; Mutagens - metabolism ; Pyrenes - metabolism ; Rat ; Rats ; Rats, Inbred Strains ; Salmonella ; Toxicology</subject><ispartof>Toxicology letters, 1986-07, Vol.32 (1), p.89-96</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-9b17263721114bfaba8aff99d5453ba4965e5a5fe253d579cf6f2ff3bcf367ba3</citedby><cites>FETCH-LOGICAL-c332t-9b17263721114bfaba8aff99d5453ba4965e5a5fe253d579cf6f2ff3bcf367ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0378427486900536$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7952127$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3738934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belisario, M.A.</creatorcontrib><creatorcontrib>Carrano, L.</creatorcontrib><creatorcontrib>de Giulio, A.</creatorcontrib><creatorcontrib>Buonocore, V.</creatorcontrib><title>Role of rat liver inducible enzymes in in vitro metabolic transformation of 1-nitropyrene</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>Liver enzymes (S9) of rats induced with various drugs differently affected the mutagenic response of 1-nitropyrene (1-NP) in vitro. The role of inducible enzymes in 1-NP conversion was evaluated by high-performance liquid chromatography (HPLC) analyses of 1-NP metabolites formed during incubation in vitro of the chemical with each S9 fraction. Methylcholanthrene (MC)-induced S9 preferentially results in 1-NP hydroxylation in position 6 or 8. Metabolic interconversions among 1-NP metabolites could be inferred from the HPLC patterns.</description><subject>1-nitropyrene</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>Chemical mutagenesis</subject><subject>Cytochrome P-450 Enzyme System - physiology</subject><subject>Enzyme Induction</subject><subject>Hydroxylation</subject><subject>In Vitro Techniques</subject><subject>liver</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MFO-inducers</subject><subject>Mutagens - metabolism</subject><subject>Pyrenes - metabolism</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Salmonella</subject><subject>Toxicology</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LJDEQhoOs6Oj6DxT6IIsees13OhdhkfUDhAVxD55Ckq5ApLszJj0D46_fbmeY40JBQdVTL8WD0DnBPwkm8gYz1dScKn7VyGuNsWC1PEAL0ihdMyL1N7TYI8fopJR3jLHkUhyhI6ZYoxlfoLeX1EGVQpXtWHVxDbmKQ7vy0U1jGD43PZRpMtc6jjlVPYzWpS76asx2KCHl3o4xDXMGqYeZWW4yDPAdHQbbFTjb9VP09_73691j_fzn4enu13PtGaNjrR1RVDJFCSHcBetsY0PQuhVcMGe5lgKEFQGoYK1Q2gcZaAjM-cCkcpadoh_b3GVOHysoo-lj8dB1doC0KoZwQTXWzQTyLehzKiVDMMsce5s3hmAzGzWzLjPrMo00X0aNnM4udvkr10O7P9opnPaXu70t3nZhsuJj2WNKC0qomrDbLQaTi3WEbIqPMHhoYwY_mjbF___xDye5kvw</recordid><startdate>198607</startdate><enddate>198607</enddate><creator>Belisario, M.A.</creator><creator>Carrano, L.</creator><creator>de Giulio, A.</creator><creator>Buonocore, V.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>198607</creationdate><title>Role of rat liver inducible enzymes in in vitro metabolic transformation of 1-nitropyrene</title><author>Belisario, M.A. ; Carrano, L. ; de Giulio, A. ; Buonocore, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-9b17263721114bfaba8aff99d5453ba4965e5a5fe253d579cf6f2ff3bcf367ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>1-nitropyrene</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biotransformation</topic><topic>Chemical mutagenesis</topic><topic>Cytochrome P-450 Enzyme System - physiology</topic><topic>Enzyme Induction</topic><topic>Hydroxylation</topic><topic>In Vitro Techniques</topic><topic>liver</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MFO-inducers</topic><topic>Mutagens - metabolism</topic><topic>Pyrenes - metabolism</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Salmonella</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belisario, M.A.</creatorcontrib><creatorcontrib>Carrano, L.</creatorcontrib><creatorcontrib>de Giulio, A.</creatorcontrib><creatorcontrib>Buonocore, V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belisario, M.A.</au><au>Carrano, L.</au><au>de Giulio, A.</au><au>Buonocore, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of rat liver inducible enzymes in in vitro metabolic transformation of 1-nitropyrene</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1986-07</date><risdate>1986</risdate><volume>32</volume><issue>1</issue><spage>89</spage><epage>96</epage><pages>89-96</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Liver enzymes (S9) of rats induced with various drugs differently affected the mutagenic response of 1-nitropyrene (1-NP) in vitro. The role of inducible enzymes in 1-NP conversion was evaluated by high-performance liquid chromatography (HPLC) analyses of 1-NP metabolites formed during incubation in vitro of the chemical with each S9 fraction. Methylcholanthrene (MC)-induced S9 preferentially results in 1-NP hydroxylation in position 6 or 8. Metabolic interconversions among 1-NP metabolites could be inferred from the HPLC patterns.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>3738934</pmid><doi>10.1016/0378-4274(86)90053-6</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 1986-07, Vol.32 (1), p.89-96 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14529098 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 1-nitropyrene Animals Biological and medical sciences Biotransformation Chemical mutagenesis Cytochrome P-450 Enzyme System - physiology Enzyme Induction Hydroxylation In Vitro Techniques liver Liver - enzymology Male Medical sciences MFO-inducers Mutagens - metabolism Pyrenes - metabolism Rat Rats Rats, Inbred Strains Salmonella Toxicology |
| title | Role of rat liver inducible enzymes in in vitro metabolic transformation of 1-nitropyrene |
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