Emu oil expedites small intestinal repair following 5-fluorouracil-induced mucositis in rats

Mucositis resulting from cancer chemotherapy is characterized by intestinal inflammation and ulceration. Previously, emu oil (EO) improved intestinal architecture (Br J Nutr, 2010) in a rat model of chemotherapy-induced mucositis. We investigated EO for its further potential to promote intestinal re...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2013-11, Vol.238 (11), p.1305-1317
Hauptverfasser:	Mashtoub, Suzanne, Tran, Cuong D, Howarth, Gordon S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - metabolism Energy Metabolism Female Fluorouracil Intestine, Small - drug effects Intestine, Small - pathology Jejunum - drug effects Jejunum - pathology Mucositis - chemically induced Mucositis - metabolism Mucositis - pathology Oils - pharmacology Oils - therapeutic use Organ Size - drug effects Rats Rats, Inbred Strains Time Factors Wound Healing - drug effects
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Zusammenfassung:	Mucositis resulting from cancer chemotherapy is characterized by intestinal inflammation and ulceration. Previously, emu oil (EO) improved intestinal architecture (Br J Nutr, 2010) in a rat model of chemotherapy-induced mucositis. We investigated EO for its further potential to promote intestinal repair in this mucositis model. Female Dark Agouti rats (n = 8/group) were gavaged with water, olive oil (OO) or EO once daily (1 mL), injected with 5-fluorouracil (5-FU) or saline on day 5 and euthanized on day 8, 9, 10 or 11. Intestinal villus height (VH) and crypt depth (CD), neutral mucin-secreting goblet cell (GC) count, myeloperoxidase (MPO) activity and selected cytokines were quantified; P
ISSN:	1535-3702 1535-3699
DOI:	10.1177/1535370213493718