Sirt1–Claudin-1 crosstalk regulates renal function
Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and gl...
Gespeichert in:
| Veröffentlicht in: | Nature medicine 2013-11, Vol.19 (11), p.1371-1372 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1372 |
|---|---|
| container_issue | 11 |
| container_start_page | 1371 |
| container_title | Nature medicine |
| container_volume | 19 |
| creator | Nihalani, Deepak Susztak, Katalin |
| description | Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and glomerular function (
pages 1496–1504
). |
| doi_str_mv | 10.1038/nm.3386 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1449768778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1449768778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-4944d98d5a30e8d4a959d4c11694470340d17fb0e25c3c6d3a622a26ea02d1123</originalsourceid><addsrcrecordid>eNpdkMtOwzAQRS0EoqUg_gBVYgGblPEjtrNEES-pEgtAYme5sVOlOE6xkwU7_oE_5EtIaXmoq7nSPbozcxE6xjDBQOWFryeUSr6DhjhlPMECnnd7DUImMkv5AB3EuAAACmm2jwaEESBUsiFiD1Vo8ef7R-50Zyqf4HERmhhb7V7Gwc47p1sbe-W1G5edL9qq8Ydor9Qu2qPNHKGn66vH_DaZ3t_c5ZfTpKCMtAnLGDOZNKmmYKVhOkszwwqMeW8IoAwMFuUMLEkLWnBDNSdEE241EIMxoSN0vs5dhua1s7FVdRUL65z2tumiwoxlgkshZI-ebqGLpgv90WuKUiBiFXi2pr5_DLZUy1DVOrwpDGpVpPK1WhXZkyebvG5WW_PL_TT3d1vsLT-34d_CrawvWIt5Qw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449330272</pqid></control><display><type>article</type><title>Sirt1–Claudin-1 crosstalk regulates renal function</title><source>MEDLINE</source><source>Nature</source><source>SpringerLink Journals - AutoHoldings</source><creator>Nihalani, Deepak ; Susztak, Katalin</creator><creatorcontrib>Nihalani, Deepak ; Susztak, Katalin</creatorcontrib><description>Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and glomerular function (
pages 1496–1504
).</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm.3386</identifier><identifier>PMID: 24202384</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/699/1585 ; Albuminuria - genetics ; Albuminuria - metabolism ; Animals ; Biomedicine ; Cancer Research ; Claudin-1 - genetics ; Claudin-1 - metabolism ; Diabetes ; Diabetes Mellitus - genetics ; Diabetes Mellitus - metabolism ; Diabetic neuropathy ; Epigenetics ; Female ; Humans ; Infectious Diseases ; Kidney diseases ; Kidney Tubules, Proximal - metabolism ; Kidneys ; Male ; Metabolic Diseases ; Molecular Medicine ; Neurosciences ; news-and-views ; Podocytes - metabolism ; Proteins ; Renal function ; Sirtuin 1 - metabolism</subject><ispartof>Nature medicine, 2013-11, Vol.19 (11), p.1371-1372</ispartof><rights>Springer Nature America, Inc. 2013</rights><rights>Copyright Nature Publishing Group Nov 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-4944d98d5a30e8d4a959d4c11694470340d17fb0e25c3c6d3a622a26ea02d1123</citedby><cites>FETCH-LOGICAL-c342t-4944d98d5a30e8d4a959d4c11694470340d17fb0e25c3c6d3a622a26ea02d1123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm.3386$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm.3386$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24202384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nihalani, Deepak</creatorcontrib><creatorcontrib>Susztak, Katalin</creatorcontrib><title>Sirt1–Claudin-1 crosstalk regulates renal function</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and glomerular function (
pages 1496–1504
).</description><subject>692/699/1585</subject><subject>Albuminuria - genetics</subject><subject>Albuminuria - metabolism</subject><subject>Animals</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Claudin-1 - genetics</subject><subject>Claudin-1 - metabolism</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - genetics</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetic neuropathy</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Kidney diseases</subject><subject>Kidney Tubules, Proximal - metabolism</subject><subject>Kidneys</subject><subject>Male</subject><subject>Metabolic Diseases</subject><subject>Molecular Medicine</subject><subject>Neurosciences</subject><subject>news-and-views</subject><subject>Podocytes - metabolism</subject><subject>Proteins</subject><subject>Renal function</subject><subject>Sirtuin 1 - metabolism</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkMtOwzAQRS0EoqUg_gBVYgGblPEjtrNEES-pEgtAYme5sVOlOE6xkwU7_oE_5EtIaXmoq7nSPbozcxE6xjDBQOWFryeUSr6DhjhlPMECnnd7DUImMkv5AB3EuAAACmm2jwaEESBUsiFiD1Vo8ef7R-50Zyqf4HERmhhb7V7Gwc47p1sbe-W1G5edL9qq8Ydor9Qu2qPNHKGn66vH_DaZ3t_c5ZfTpKCMtAnLGDOZNKmmYKVhOkszwwqMeW8IoAwMFuUMLEkLWnBDNSdEE241EIMxoSN0vs5dhua1s7FVdRUL65z2tumiwoxlgkshZI-ebqGLpgv90WuKUiBiFXi2pr5_DLZUy1DVOrwpDGpVpPK1WhXZkyebvG5WW_PL_TT3d1vsLT-34d_CrawvWIt5Qw</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Nihalani, Deepak</creator><creator>Susztak, Katalin</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Sirt1–Claudin-1 crosstalk regulates renal function</title><author>Nihalani, Deepak ; Susztak, Katalin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-4944d98d5a30e8d4a959d4c11694470340d17fb0e25c3c6d3a622a26ea02d1123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>692/699/1585</topic><topic>Albuminuria - genetics</topic><topic>Albuminuria - metabolism</topic><topic>Animals</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Claudin-1 - genetics</topic><topic>Claudin-1 - metabolism</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - genetics</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetic neuropathy</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Kidney diseases</topic><topic>Kidney Tubules, Proximal - metabolism</topic><topic>Kidneys</topic><topic>Male</topic><topic>Metabolic Diseases</topic><topic>Molecular Medicine</topic><topic>Neurosciences</topic><topic>news-and-views</topic><topic>Podocytes - metabolism</topic><topic>Proteins</topic><topic>Renal function</topic><topic>Sirtuin 1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nihalani, Deepak</creatorcontrib><creatorcontrib>Susztak, Katalin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nihalani, Deepak</au><au>Susztak, Katalin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sirt1–Claudin-1 crosstalk regulates renal function</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>19</volume><issue>11</issue><spage>1371</spage><epage>1372</epage><pages>1371-1372</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and glomerular function (
pages 1496–1504
).</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>24202384</pmid><doi>10.1038/nm.3386</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 2013-11, Vol.19 (11), p.1371-1372 |
| issn | 1078-8956 1546-170X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1449768778 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | 692/699/1585 Albuminuria - genetics Albuminuria - metabolism Animals Biomedicine Cancer Research Claudin-1 - genetics Claudin-1 - metabolism Diabetes Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetic neuropathy Epigenetics Female Humans Infectious Diseases Kidney diseases Kidney Tubules, Proximal - metabolism Kidneys Male Metabolic Diseases Molecular Medicine Neurosciences news-and-views Podocytes - metabolism Proteins Renal function Sirtuin 1 - metabolism |
| title | Sirt1–Claudin-1 crosstalk regulates renal function |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T17%3A31%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sirt1%E2%80%93Claudin-1%20crosstalk%20regulates%20renal%20function&rft.jtitle=Nature%20medicine&rft.au=Nihalani,%20Deepak&rft.date=2013-11-01&rft.volume=19&rft.issue=11&rft.spage=1371&rft.epage=1372&rft.pages=1371-1372&rft.issn=1078-8956&rft.eissn=1546-170X&rft_id=info:doi/10.1038/nm.3386&rft_dat=%3Cproquest_cross%3E1449768778%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449330272&rft_id=info:pmid/24202384&rfr_iscdi=true |