Sirt1–Claudin-1 crosstalk regulates renal function

Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and gl...

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Veröffentlicht in:	Nature medicine 2013-11, Vol.19 (11), p.1371-1372
Hauptverfasser:	Nihalani, Deepak, Susztak, Katalin
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/1585 Albuminuria - genetics Albuminuria - metabolism Animals Biomedicine Cancer Research Claudin-1 - genetics Claudin-1 - metabolism Diabetes Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetic neuropathy Epigenetics Female Humans Infectious Diseases Kidney diseases Kidney Tubules, Proximal - metabolism Kidneys Male Metabolic Diseases Molecular Medicine Neurosciences news-and-views Podocytes - metabolism Proteins Renal function Sirtuin 1 - metabolism
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Beschreibung
Zusammenfassung:	Understanding the molecular mechanisms that govern diabetes-induced loss of kidney function is crucial. A new study shows that in mouse models of diabetes, sirtuin 1 (Sirt1) in the proximal tubules of the kidney can modulate the expression of podocyte Claudin-1, a key regulator of albuminuria and glomerular function ( pages 1496–1504 ).
ISSN:	1078-8956 1546-170X
DOI:	10.1038/nm.3386