Rapid CO release from a Mn(I) carbonyl complex derived from azopyridine upon exposure to visible light and its phototoxicity toward malignant cells

Two Mn(I) carbonyl complexes namely [MnBr(azpy)(CO)3] and [Mn(azpy)(CO)3(PPh3)](ClO4) (azpy = 2-phenylazopyridine) have been synthesized and characterized. Both complexes exhibit rapid CO release upon exposure to low power visible light. [MnBr(azpy)(CO)3] shows significant phototoxicity toward two m...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (96), p.11254-11256
Hauptverfasser:	Carrington, Samantha J, Chakraborty, Indranil, Mascharak, Pradip K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Carbon Monoxide - administration & dosage Carbon Monoxide - chemistry Carbon Monoxide - pharmacology Cell Line, Tumor Cell Survival - drug effects Coordination Complexes - chemistry Coordination Complexes - pharmacology Humans Manganese - chemistry Manganese - pharmacology Models, Molecular Neoplasms - drug therapy Neoplasms - radiotherapy Pyridines - chemistry Pyridines - pharmacology
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Zusammenfassung:	Two Mn(I) carbonyl complexes namely [MnBr(azpy)(CO)3] and [Mn(azpy)(CO)3(PPh3)](ClO4) (azpy = 2-phenylazopyridine) have been synthesized and characterized. Both complexes exhibit rapid CO release upon exposure to low power visible light. [MnBr(azpy)(CO)3] shows significant phototoxicity toward two malignant cell lines HeLa and MDA-MB-231.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc46558f