Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis--a dose response study in rats

A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1beta and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the leve...

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Veröffentlicht in:	Indian journal of experimental biology 2013-04, Vol.51 (4), p.292-302
Hauptverfasser:	Suguna, Periyanayagam, Geetha, Arumugam, Aruna, Ravikumar, Siva, Ganesan Vijaiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Benzoquinones - pharmacology Body Weight Diet, High-Fat - adverse effects Dose-Response Relationship, Drug Ethanol - adverse effects Glutathione - metabolism Inflammation Interleukin-18 - metabolism Interleukin-1beta - metabolism Lipase - blood Lipid Peroxides - chemistry Male Oxidative Stress Pancreatitis, Chronic - chemically induced Pancreatitis, Chronic - drug therapy Peroxidase - metabolism Rats Rats, Wistar
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Zusammenfassung:	A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1beta and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ.
ISSN:	0019-5189