How do filovirus filaments bend without breaking?

Highlights • The monopartite genome of the Mononegavirales is coiled within a helical nucleocapsid during infection. • Filamentous filoviruses have multiple genome copies joined end-to-end in a modular fashion. • The outer helical layer of the filovirus nucleocapsid allows tight bending of the nucle...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2013-11, Vol.21 (11), p.583-593
Hauptverfasser:	Booth, Tim F, Rabb, Melissa J, Beniac, Daniel R
Format:	Artikel
Sprache:	eng
Schlagworte:	cryo-electron microscopy Ebola virus Ebolavirus Filoviridae - physiology Filoviridae - ultrastructure filovirus genome Internal Medicine Macromolecular Substances - metabolism Models, Biological Models, Molecular nucleocapsid Nucleocapsid - metabolism nucleoproteins pathogens polyploidy Rhabdoviridae Rhabdoviridae - physiology Rhabdoviridae - ultrastructure RNA virion Virus Assembly virus structure viruses
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Beschreibung
Zusammenfassung:	Highlights • The monopartite genome of the Mononegavirales is coiled within a helical nucleocapsid during infection. • Filamentous filoviruses have multiple genome copies joined end-to-end in a modular fashion. • The outer helical layer of the filovirus nucleocapsid allows tight bending of the nucleocapsid. • Structural analysis shows how RNA transcription and replication is achieved while protecting the genome.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2013.08.001