Cytokeratin 19, Carcinoembryonic Antigen, and Epithelial Cell Adhesion Molecule Detect Lung Cancer Lymph Node Metastasis in Endobronchial Ultrasound-Guided Transbronchial Aspiration Samples

Micro-Abstract We evaluated the feasibility of using molecular markers to detect non–small-cell lung cancer (NSCLC) lymph node metastasis in endobronchial ultrasound-guided transbronchial needle aspiration samples. Thirty-three NSCLC patients and 17 control subjects were included. Cytokeratin-19, ca...

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Veröffentlicht in:	Clinical lung cancer 2013-11, Vol.14 (6), p.704-712
Hauptverfasser:	Bugalho, Antonio, Martins, Catarina, Dias, Sara S, Nunes, Gloria, Silva, Zelia, Correia, Manuela, Marques Gomes, Maria J, Videira, Paula A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigens, Neoplasm - metabolism Biomarkers, Tumor - metabolism Biopsy, Fine-Needle Bronchi - diagnostic imaging Carcinoembryonic Antigen - metabolism Carcinoma, Non-Small-Cell Lung - diagnosis Cell Adhesion Molecules - metabolism Cell Separation Endobronchial ultrasound Endosonography - methods Epithelial Cell Adhesion Molecule Epithelial Cells - pathology Female Fine needle aspiration Flow Cytometry Hematology, Oncology and Palliative Medicine Humans Keratin-19 - metabolism Lung Neoplasms - diagnosis Lymph Nodes - pathology Lymphatic Metastasis Lymphocytes - immunology Male Middle Aged Monocytes - immunology Non–small-cell lung cancer Prospective Studies Pulmonary/Respiratory Reverse Transcriptase Polymerase Chain Reaction Tumor markers
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Zusammenfassung:	Micro-Abstract We evaluated the feasibility of using molecular markers to detect non–small-cell lung cancer (NSCLC) lymph node metastasis in endobronchial ultrasound-guided transbronchial needle aspiration samples. Thirty-three NSCLC patients and 17 control subjects were included. Cytokeratin-19, carcinoembryonic antigen, and epithelial cell adhesion molecule identified NSCLC lymphatic involvement. This might be important to improve the negative predictive value and accurately subtype these samples.
ISSN:	1525-7304 1938-0690
DOI:	10.1016/j.cllc.2013.06.004