Gastric cancer: adding glycosylation to the equation

Highlights • Glycosylation changes are a hallmark of cancer cells. • Glycosylation plays a key role in fundamental pathophysiological steps of GC. • Deciphering GC cell “glycans code” contributes to its molecular understanding. • Glycan biomarkers hold an opportunity for improving early cancer diagn...

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Veröffentlicht in:	Trends in molecular medicine 2013-11, Vol.19 (11), p.664-676
Hauptverfasser:	Pinho, Salomé S, Carvalho, Sandra, Marcos-Pinto, Ricardo, Magalhães, Ana, Oliveira, Carla, Gu, Jianguo, Dinis-Ribeiro, Mário, Carneiro, Fátima, Seruca, Raquel, Reis, Celso A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biomarkers cancer e-cadherin gastric cancer Gastric Mucosa - metabolism Gastric Mucosa - microbiology Glycosylation Helicobacter Infections - genetics Helicobacter Infections - metabolism Helicobacter Infections - microbiology Helicobacter pylori - physiology Humans integrins Pathology Proteins - genetics Proteins - metabolism Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - microbiology
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Beschreibung
Zusammenfassung:	Highlights • Glycosylation changes are a hallmark of cancer cells. • Glycosylation plays a key role in fundamental pathophysiological steps of GC. • Deciphering GC cell “glycans code” contributes to its molecular understanding. • Glycan biomarkers hold an opportunity for improving early cancer diagnosis and therapy.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2013.07.003