Copper(I) Iodide-Catalysed Aerobic Oxidative Synthesis of Imidazo[1,2-a]pyridines from 2-Aminopyridines and Methyl Ketones

Copper(I) Iodide-Catalysed Aerobic Oxidative Synthesis of Imidazo[1,2-a]pyridines from 2-Aminopyridines and Methyl Ketones

We report here an operationally simple copper‐catalysed synthesis of imidazo[1,2‐a]pyridines through CH activation with oxidative linkage of two CN bonds under very mild conditions using molecular oxygen as a sole oxidant. The process allows the quick assembly of imidazo[1,2‐a]pyridines including...

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Veröffentlicht in:Advanced synthesis & catalysis 2013-08, Vol.355 (11-12), p.2217-2221
Hauptverfasser: Chandra Mohan, Darapaneni, Reddy Donthiri, Ramachandra, Nageswara Rao, Sadu, Adimurthy, Subbarayappa
Format: Artikel
Sprache:eng
Schlagworte:
2-a]pyridines
Activation
aerobic oxidation
Assembly
copper
CH activation
Functional groups
imidazo
imidazo[1,2‐a]pyridines
Ketones
Linkages
Sole
Synthesis
Tolerances
zolimidine synthesis
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Zusammenfassung:We report here an operationally simple copper‐catalysed synthesis of imidazo[1,2‐a]pyridines through CH activation with oxidative linkage of two CN bonds under very mild conditions using molecular oxygen as a sole oxidant. The process allows the quick assembly of imidazo[1,2‐a]pyridines including the antiulcer drug zolimidine from inexpensive and readily available 2‐aminopyridines and methyl ketones with broad range of functional group tolerance.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201300456