A highly specific BODIPY-based probe localized in mitochondria for HClO imaging

A highly specific BODIPY-based probe localized in mitochondria for HClO imaging

An oxime containing fluorescent probe based on a BODIPY scaffold was successfully designed and used for HClO determination with rapid response, low detection limits and high selectivity. Confocal fluorescence microscopy demonstrated that the probe could permeate the mitochondria and made possible th...

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Veröffentlicht in:Analyst (London) 2013-10, Vol.138 (20), p.6091-6096
Hauptverfasser: Cheng, Guanghui, Fan, Jiangli, Sun, Wen, Sui, Kun, Jin, Xin, Wang, Jingyun, Peng, Xiaojun
Format: Artikel
Sprache:eng
Schlagworte:
Boron Compounds - chemistry
Confocal
Fluorescence
Fluorescent Dyes - chemistry
Humans
Hypochlorous Acid - chemistry
Imaging
MCF-7 Cells
Microscopy
Mitochondria
Mitochondria - chemistry
Oximes
Scaffolds
Spectrometry, Fluorescence - methods
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Beschreibung
Zusammenfassung:An oxime containing fluorescent probe based on a BODIPY scaffold was successfully designed and used for HClO determination with rapid response, low detection limits and high selectivity. Confocal fluorescence microscopy demonstrated that the probe could permeate the mitochondria and made possible the fast fluorescent imaging of endogenous HClO.
ISSN:0003-2654
1364-5528
DOI:10.1039/c3an01152f