Toxicity, distribution, and accumulation of silver nanoparticles in Wistar rats
The bactericidal effect of silver nanoparticles (SNP) has lead to their application in several products mainly in the medicine field. This study analyzed the distribution, accumulation, and toxicity in principal organs of Wistar rats exposed to SNP suspensions by oral administration. Two sizes of wa...
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| creator | Espinosa-Cristobal, L. F. Martinez-Castañon, G. A. Loyola-Rodriguez, J. P. Patiño-Marin, N. Reyes-Macías, J. F. Vargas-Morales, J. M. Ruiz, Facundo |
| description | The bactericidal effect of silver nanoparticles (SNP) has lead to their application in several products mainly in the medicine field. This study analyzed the distribution, accumulation, and toxicity in principal organs of Wistar rats exposed to SNP suspensions by oral administration. Two sizes of washed SNP (14 and 36 nm) were prepared, characterized, and redispersed in deionized water. Each suspension was administrated to Wistar rats by oral way for 55 days; after finishing this treatment time, rats were sacrificed by anesthesia overdose. Organs were collected, processed, and prepared; then, accumulation and concentrations of SNP were obtained using inductively coupled plasma mass spectrometry (ICP-MS). Toxicity was determined by clinical chemistry and hematology from blood samples in three different periods; light microscopy (LM) and scanning electron microscopy (SEM) were applied to evaluate histopathology in tissues. Silver concentrations were higher in small intestine, followed by kidney, liver, and brain. Clinical chemistry and hematology showed altered values in blood urea nitrogen, total proteins, and mean corpuscular hemoglobin, concentration values had statistical difference in both groups (14 and 36 nm) (
p
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| doi_str_mv | 10.1007/s11051-013-1702-6 |
| format | Article |
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p
< 0.05). LM, SEM, ICP-MS, clinical chemistry, and hematology tests suggest that the administration way, concentration, shape, size, presentation, administration time of SNP used in this study, do not change significantly these values.</description><identifier>ISSN: 1388-0764</identifier><identifier>EISSN: 1572-896X</identifier><identifier>DOI: 10.1007/s11051-013-1702-6</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Accumulation ; Anesthesia ; Blood ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Cross-disciplinary physics: materials science; rheology ; Exact sciences and technology ; Hematology ; Histopathology ; Inorganic Chemistry ; Lasers ; Light microscopy ; Mass spectrometry ; Materials Science ; Nanocrystalline materials ; Nanoparticles ; Nanoscale materials and structures: fabrication and characterization ; Nanotechnology ; Optical Devices ; Optics ; Overdose ; Photonics ; Physical Chemistry ; Physics ; Research Paper ; Silver ; Toxicity ; Urea</subject><ispartof>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2013-06, Vol.15 (6), p.1-12, Article 1702</ispartof><rights>Springer Science+Business Media Dordrecht 2013</rights><rights>2014 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-35387eb3744dccf4348ea6d4608958e8168403cc39ff130a7ff4db9ee1d591b43</citedby><cites>FETCH-LOGICAL-c427t-35387eb3744dccf4348ea6d4608958e8168403cc39ff130a7ff4db9ee1d591b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11051-013-1702-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11051-013-1702-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27644788$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Espinosa-Cristobal, L. F.</creatorcontrib><creatorcontrib>Martinez-Castañon, G. A.</creatorcontrib><creatorcontrib>Loyola-Rodriguez, J. P.</creatorcontrib><creatorcontrib>Patiño-Marin, N.</creatorcontrib><creatorcontrib>Reyes-Macías, J. F.</creatorcontrib><creatorcontrib>Vargas-Morales, J. M.</creatorcontrib><creatorcontrib>Ruiz, Facundo</creatorcontrib><title>Toxicity, distribution, and accumulation of silver nanoparticles in Wistar rats</title><title>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</title><addtitle>J Nanopart Res</addtitle><description>The bactericidal effect of silver nanoparticles (SNP) has lead to their application in several products mainly in the medicine field. This study analyzed the distribution, accumulation, and toxicity in principal organs of Wistar rats exposed to SNP suspensions by oral administration. Two sizes of washed SNP (14 and 36 nm) were prepared, characterized, and redispersed in deionized water. Each suspension was administrated to Wistar rats by oral way for 55 days; after finishing this treatment time, rats were sacrificed by anesthesia overdose. Organs were collected, processed, and prepared; then, accumulation and concentrations of SNP were obtained using inductively coupled plasma mass spectrometry (ICP-MS). Toxicity was determined by clinical chemistry and hematology from blood samples in three different periods; light microscopy (LM) and scanning electron microscopy (SEM) were applied to evaluate histopathology in tissues. Silver concentrations were higher in small intestine, followed by kidney, liver, and brain. Clinical chemistry and hematology showed altered values in blood urea nitrogen, total proteins, and mean corpuscular hemoglobin, concentration values had statistical difference in both groups (14 and 36 nm) (
p
< 0.05). LM, SEM, ICP-MS, clinical chemistry, and hematology tests suggest that the administration way, concentration, shape, size, presentation, administration time of SNP used in this study, do not change significantly these values.</description><subject>Accumulation</subject><subject>Anesthesia</subject><subject>Blood</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cross-disciplinary physics: materials science; rheology</subject><subject>Exact sciences and technology</subject><subject>Hematology</subject><subject>Histopathology</subject><subject>Inorganic Chemistry</subject><subject>Lasers</subject><subject>Light microscopy</subject><subject>Mass spectrometry</subject><subject>Materials Science</subject><subject>Nanocrystalline materials</subject><subject>Nanoparticles</subject><subject>Nanoscale materials and structures: fabrication and characterization</subject><subject>Nanotechnology</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Overdose</subject><subject>Photonics</subject><subject>Physical Chemistry</subject><subject>Physics</subject><subject>Research Paper</subject><subject>Silver</subject><subject>Toxicity</subject><subject>Urea</subject><issn>1388-0764</issn><issn>1572-896X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE9LwzAchosoOKcfwFtABA-r5pekTXoU8R8MdpnoLaRpIhldOpNW3Lc3ZUNE8JSQPO_Ly5Nl54CvAWN-EwFwATkGmgPHJC8PsgkUnOSiKt8O050KkWNesuPsJMYVxlCSikyyxbL7ctr12xlqXOyDq4fedX6GlG-Q0npYD60aX1BnUXTtpwnIK99tVOidbk1EzqPXlFQBBdXH0-zIqjaas_05zV4e7pd3T_l88fh8dzvPNSO8z2lBBTc15Yw1WltGmTCqbFiJRVUII6AUDFOtaWUtUKy4taypK2OgKSqoGZ1mV7veTeg-BhN7uXZRm7ZV3nRDlMCY4ISmvoRe_EFX3RB8WieBciwIAVEmCnaUDl2MwVi5CW6twlYClqNiuVMsk2I5KpZj5nLfrKJWrQ3Kaxd_giTpZlyMC8iOi-nLv5vwa8G_5d97kIrY</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Espinosa-Cristobal, L. 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F.</au><au>Martinez-Castañon, G. A.</au><au>Loyola-Rodriguez, J. P.</au><au>Patiño-Marin, N.</au><au>Reyes-Macías, J. F.</au><au>Vargas-Morales, J. M.</au><au>Ruiz, Facundo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicity, distribution, and accumulation of silver nanoparticles in Wistar rats</atitle><jtitle>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</jtitle><stitle>J Nanopart Res</stitle><date>2013-06-01</date><risdate>2013</risdate><volume>15</volume><issue>6</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><artnum>1702</artnum><issn>1388-0764</issn><eissn>1572-896X</eissn><abstract>The bactericidal effect of silver nanoparticles (SNP) has lead to their application in several products mainly in the medicine field. This study analyzed the distribution, accumulation, and toxicity in principal organs of Wistar rats exposed to SNP suspensions by oral administration. Two sizes of washed SNP (14 and 36 nm) were prepared, characterized, and redispersed in deionized water. Each suspension was administrated to Wistar rats by oral way for 55 days; after finishing this treatment time, rats were sacrificed by anesthesia overdose. Organs were collected, processed, and prepared; then, accumulation and concentrations of SNP were obtained using inductively coupled plasma mass spectrometry (ICP-MS). Toxicity was determined by clinical chemistry and hematology from blood samples in three different periods; light microscopy (LM) and scanning electron microscopy (SEM) were applied to evaluate histopathology in tissues. Silver concentrations were higher in small intestine, followed by kidney, liver, and brain. Clinical chemistry and hematology showed altered values in blood urea nitrogen, total proteins, and mean corpuscular hemoglobin, concentration values had statistical difference in both groups (14 and 36 nm) (
p
< 0.05). LM, SEM, ICP-MS, clinical chemistry, and hematology tests suggest that the administration way, concentration, shape, size, presentation, administration time of SNP used in this study, do not change significantly these values.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s11051-013-1702-6</doi><tpages>12</tpages></addata></record> |
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| subjects | Accumulation Anesthesia Blood Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Cross-disciplinary physics: materials science rheology Exact sciences and technology Hematology Histopathology Inorganic Chemistry Lasers Light microscopy Mass spectrometry Materials Science Nanocrystalline materials Nanoparticles Nanoscale materials and structures: fabrication and characterization Nanotechnology Optical Devices Optics Overdose Photonics Physical Chemistry Physics Research Paper Silver Toxicity Urea |
| title | Toxicity, distribution, and accumulation of silver nanoparticles in Wistar rats |
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