Novel porphyrin-psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies

A Cu(i)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin-psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).

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Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2013-10, Vol.11 (39), p.6675-6679
Hauptverfasser:	Kumar, Dalip, Mishra, Bhupendra A, Chandra Shekar, K P, Kumar, Anil, Akamatsu, Kanako, Kurihara, Ryohsuke, Ito, Takeo
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cancer Catalysis Cell Line, Tumor Cell Survival - drug effects Copper - chemistry DNA - chemistry Ficusin - chemical synthesis Ficusin - chemistry Ficusin - pharmacology Fluorescence Humans Inhibitory Concentration 50 Molecular Structure Porphyrins - chemical synthesis Porphyrins - chemistry Porphyrins - pharmacology
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Beschreibung
Zusammenfassung:	A Cu(i)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin-psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c3ob41224e