Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients

The aim of the study was to characterise gastro-oesophageal reflux (GOR) in idiopathic pulmonary fibrosis (IPF). 40 consecutive IPF patients underwent pulmonary high-resolution computed tomography (HRCT) scan and impedance-pH monitoring while off antisecretory therapy. The presence of pulmonary fibr...

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Veröffentlicht in:	The European respiratory journal 2013-11, Vol.42 (5), p.1322-1331
Hauptverfasser:	SAVARINO, Edoardo, CARBONE, Roberto, MARABOTTO, Elisa, FURNARI, Manuele, SCONFIENZA, Luca, GHIO, Massimo, ZENTILIN, Patrizia, SAVARINO, Vincenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Bile Acids and Salts - metabolism Biological and medical sciences Bronchoalveolar Lavage Fluid Case-Control Studies Electric Impedance Esophagus Esophagus - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - complications Gastroesophageal Reflux - diagnostic imaging Humans Hydrogen-Ion Concentration Idiopathic Pulmonary Fibrosis - complications Idiopathic Pulmonary Fibrosis - diagnostic imaging Idiopathic Pulmonary Fibrosis - pathology Male Manometry Medical sciences Middle Aged Other diseases. Semiology Pepsin A - metabolism Pneumology Prevalence Respiratory Aspiration of Gastric Contents - complications Respiratory Aspiration of Gastric Contents - pathology Respiratory system : syndromes and miscellaneous diseases Saliva - metabolism Stomach - pathology Tomography, X-Ray Computed
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Zusammenfassung:	The aim of the study was to characterise gastro-oesophageal reflux (GOR) in idiopathic pulmonary fibrosis (IPF). 40 consecutive IPF patients underwent pulmonary high-resolution computed tomography (HRCT) scan and impedance-pH monitoring while off antisecretory therapy. The presence of pulmonary fibrosis was assessed using validated HRCT scores. Reflux features included distal oesophageal acid exposure, number of acid/weakly acidic reflux episodes and their proximal migration. 40 consecutive patients with interstitial lung disease other than IPF (non-IPF patients) and 50 healthy volunteers were also enrolled. IPF patients had significantly higher (p
ISSN:	0903-1936 1399-3003
DOI:	10.1183/09031936.00101212