Overexpression of Metastasis-Associated in Colon Cancer-1 Associated with Poor Prognosis in Patients with Esophageal Cancer

Recent studies have shown that expression of metastasis-associated in colon cancer-1(MACC1) is observed in different types of cancer and plays an important role in tumor metastasis. However, the expression of MACC1 and its possible role in esophageal cancer remains unknown. In this study, we determi...

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Veröffentlicht in:	Pathology oncology research 2013-10, Vol.19 (4), p.749-753
Hauptverfasser:	Zhu, Mingchen, Xu, Yijun, Mao, Xuelian, Gao, Yanfang, Shao, Lijia, Yan, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomedical and Life Sciences Biomedicine Cancer Research Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Female Humans Immunohistochemistry Immunology Kaplan-Meier Estimate Male Middle Aged Neoplasm Metastasis Oncology Pathology Prognosis Regression Analysis Transcription Factors - biosynthesis Transcription Factors - metabolism
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Zusammenfassung:	Recent studies have shown that expression of metastasis-associated in colon cancer-1(MACC1) is observed in different types of cancer and plays an important role in tumor metastasis. However, the expression of MACC1 and its possible role in esophageal cancer remains unknown. In this study, we determined the expression of MACC1 in esophageal cancer by utilizing immunohistochemistry and analyzed the relationship between the expression and esophageal cancer prognosis. Immunohistochemistry results showed that 47 of 85 cancer lesions (55.2 %) were stained positive, and high expression of MACC1 was correlated with the node metastasis and TNM stage ( P
ISSN:	1219-4956 1532-2807
DOI:	10.1007/s12253-013-9638-9