Left ventricular myocardial performance index change for detection of acute cellular rejection in pediatric heart transplantation

EMB, the gold standard for diagnosis of ACR, poses unique risks in children. Limited cross‐sectional data have associated LV MPI with ACR. We hypothesize that a relative change in MPI from baseline without ACR to the time of ACR will better detect ACR than an absolute threshold LV MPI value. We iden...

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Veröffentlicht in:	Pediatric transplantation 2013-12, Vol.17 (8), p.782-786
Hauptverfasser:	Flanagan, Ryan, Cain, Nicole, Tatum, Gregory H., DeBrunner, Mark G., Drant, Stacey, Feingold, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	acute rejection Adolescent Adult Biopsy Child Child, Preschool Diastole echocardiogram Echocardiography Female Graft Rejection - diagnosis Heart Failure - therapy heart transplant Heart Transplantation Humans Infant Male myocardial performance index Myocardium - pathology Observer Variation pediatric Prospective Studies Reperfusion Injury - pathology Risk ROC Curve Sensitivity and Specificity Time Factors Treatment Outcome Ventricular Dysfunction, Left - pathology Ventricular Function, Left - physiology Young Adult
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Zusammenfassung:	EMB, the gold standard for diagnosis of ACR, poses unique risks in children. Limited cross‐sectional data have associated LV MPI with ACR. We hypothesize that a relative change in MPI from baseline without ACR to the time of ACR will better detect ACR than an absolute threshold LV MPI value. We identified 40 children with ACR ≥60 days post‐transplant matching them by age and time from transplantation to 40 children without ACR. There was a significant increase in LV MPI at time of ACR vs. baseline (0.59 ± 0.17 vs. 0.41 ± 0.11; p
ISSN:	1397-3142 1399-3046
DOI:	10.1111/petr.12153