Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension

BACKGROUND—The role of right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH) is not well established. Therefore, we investigated the presence and possible underlying mechanisms of RV diastolic stiffness in PAH patients. METHODS AND RESULTS—Single-beat RV pressure-volume...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2013-10, Vol.128 (18), p.2016-2025
Hauptverfasser:	Rain, Silvia, Handoko, M Louis, Trip, Pia, Gan, C Tji-Joong, Westerhof, Nico, Stienen, Ger J, Paulus, Walter J, Ottenheijm, Coen A.C, Marcus, J Tim, Dorfmüller, Peter, Guignabert, Christophe, Humbert, Marc, MacDonald, Peter, dos Remedios, Cris, Postmus, Piet E, Saripalli, Chandra, Hidalgo, Carlos G, Granzier, Henk L, Vonk-Noordegraaf, Anton, van der Velden, Jolanda, de Man, Frances S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiac Catheterization Cardiac Volume - physiology Cardiology. Vascular system Collagen - metabolism Connectin - metabolism Diastole - physiology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Familial Primary Pulmonary Hypertension Female Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Hypertension, Pulmonary - physiopathology Hypertrophy, Right Ventricular - metabolism Hypertrophy, Right Ventricular - pathology Hypertrophy, Right Ventricular - physiopathology Magnetic Resonance Imaging Male Medical sciences Middle Aged Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Sarcomeres - metabolism Sarcomeres - pathology Ventricular Dysfunction, Right - metabolism Ventricular Dysfunction, Right - pathology Ventricular Dysfunction, Right - physiopathology Ventricular Pressure - physiology
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Zusammenfassung:	BACKGROUND—The role of right ventricular (RV) diastolic stiffness in pulmonary arterial hypertension (PAH) is not well established. Therefore, we investigated the presence and possible underlying mechanisms of RV diastolic stiffness in PAH patients. METHODS AND RESULTS—Single-beat RV pressure-volume analyses were performed in 21 PAH patients and 7 control subjects to study RV diastolic stiffness. Data are presented as mean±SEM. RV diastolic stiffness (β) was significantly increased in PAH patients (PAH, 0.050±0.005 versus control, 0.029±0.003; P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.113.001873