Assay for toxic chemicals using bacteria

Several species of bacteria were tested for ability to reduce various tetrazolium dyes. Rhizobium meliloti readily reduced diphenylthiazole tetrazolium (MTT) and common toxic chemicals inhibited the reduction. Therefore, this organism and dye were chosen for testing with 60 organic compounds, and 11...

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Veröffentlicht in:	Bulletin of environmental contamination and toxicology 1997-12, Vol.59 (6), p.1000-1009
Hauptverfasser:	BOTSFORD, J. L, RIVERA, J, NAVAREZ, J, RILEY, R, WRIGHT, T, BAKER, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - drug effects Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Coloring Agents Culture Media General aspects Medical sciences Minerals - toxicity Oxidation-Reduction Platelet Aggregation Inhibitors - toxicity Rhizobium - drug effects Tetrazolium Salts - toxicity Thiazoles - toxicity Toxicity Tests - methods Toxicology Triazoles - toxicity
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Beschreibung
Zusammenfassung:	Several species of bacteria were tested for ability to reduce various tetrazolium dyes. Rhizobium meliloti readily reduced diphenylthiazole tetrazolium (MTT) and common toxic chemicals inhibited the reduction. Therefore, this organism and dye were chosen for testing with 60 organic compounds, and 11 metal salts. Results were obtained in 20 minutes, and were comparable to results of other bioassays using bacteria. The rapidity and convenience of the system should make it acceptable for use in developing countries.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/s001289900582