Current concepts on the pathogenesis and etiology of congenital diaphragmatic hernia

Highlights • CDH is characterized by the incomplete formation of the diaphragm in utero. • There are teratogenic, Vit A-deficient, and genetically engineered rodent models of CDH. • The diaphragm arises from the pleuroperitoneal fold (PPF). • Abnormal PPF formation during gestational weeks 3–5 leads...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2013-11, Vol.189 (2), p.232-240
1. Verfasser:	Greer, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Congenital diaphragmatic hernia (CDH) COUP-TFII Diaphragm - growth & development Hernia, Diaphragmatic - diagnosis Hernia, Diaphragmatic - etiology Hernias, Diaphragmatic, Congenital Humans Lung - growth & development Lung Diseases - diagnosis Lung Diseases - etiology Medical Education Nitrofen Pleuroperitoneal fold Pulmonary/Respiratory Vitamin A Vitamin A Deficiency - complications Vitamin A Deficiency - diagnosis WT-1
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Beschreibung
Zusammenfassung:	Highlights • CDH is characterized by the incomplete formation of the diaphragm in utero. • There are teratogenic, Vit A-deficient, and genetically engineered rodent models of CDH. • The diaphragm arises from the pleuroperitoneal fold (PPF). • Abnormal PPF formation during gestational weeks 3–5 leads to the defect. • Retinoid signaling and associated genes have been implicated in the etiology of CDH.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2013.04.015