Dipyrone (Metamizole) Can Nullify the Antiplatelet Effect of Aspirin in Patients With Coronary Artery Disease

Aspirin, a unique cost-effective antiplatelet drug, is the backbone of current clinical practice for secondary prevention of cardiovascular events and is indispensable after coronary stent implantation. [...]aspirin fails to inhibit platelet COX-1, the pharmacological target of aspirin (4).

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American College of Cardiology 2013-10, Vol.62 (18), p.1725-1726
Hauptverfasser:	Polzin, Amin, MD, Zeus, Tobias, MD, Schrör, Karsten, MD, Kelm, Malte, MD, Hohlfeld, Thomas, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analgesics Anti-Inflammatory Agents, Non-Steroidal - adverse effects Aspirin Aspirin - therapeutic use Biological and medical sciences Blood platelets Bones, joints and connective tissue. Antiinflammatory agents Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease coronary artery disease Coronary Artery Disease - drug therapy Coronary heart disease Coronary vessels dipyrone Dipyrone - adverse effects Drug Interactions Drug therapy Enzyme kinetics Heart Heart attacks high treatment-platelet reactivity Humans Internal Medicine Medical sciences metamizole Mortality nonresponder Nonsteroidal anti-inflammatory drugs Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - therapeutic use Surgery Thromboxanes - biosynthesis
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Beschreibung
Zusammenfassung:	Aspirin, a unique cost-effective antiplatelet drug, is the backbone of current clinical practice for secondary prevention of cardiovascular events and is indispensable after coronary stent implantation. [...]aspirin fails to inhibit platelet COX-1, the pharmacological target of aspirin (4).
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2013.07.039