Immunochemistry screening for Lynch syndrome in colorectal adenocarcinoma using an initial two antibody panel can replace a four antibody panel
Tests the hypothesis that staining for PMS2 and MSH6 antibodies alone will be sufficient to detect all cases of Lynch syndrome (LS) - also known as hereditary non polyposis colorectal cancer (HNPCC), an inherited autosomal dominant condition predisposing to early onset colorectal adenocarcinoma - an...
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| Veröffentlicht in: | New Zealand medical journal 2013-09, Vol.126 (1382), p.70-77 |
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| container_title | New Zealand medical journal |
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| creator | O'Regan, Toni |
| description | Tests the hypothesis that staining for PMS2 and MSH6 antibodies alone will be sufficient to detect all cases of Lynch syndrome (LS) - also known as hereditary non polyposis colorectal cancer (HNPCC), an inherited autosomal dominant condition predisposing to early onset colorectal adenocarcinoma - and that it could replace routine screening with all four antibodies (MLH1, MSH2, MSH6, PMS2) which is current standard practice in immunochemistry staining for LS. Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons Attribution 3.0 New Zealand Licence. |
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genetics</topic><topic>Adaptor Proteins, Signal Transducing - immunology</topic><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenosine Triphosphatases - genetics</topic><topic>Adenosine Triphosphatases - immunology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Cohort Studies</topic><topic>Colon (Anatomy)</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - genetics</topic><topic>Colorectal Neoplasms, Hereditary Nonpolyposis - immunology</topic><topic>Diagnosis</topic><topic>Disease susceptibility</topic><topic>DNA Repair Enzymes - genetics</topic><topic>DNA Repair Enzymes - immunology</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - immunology</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Immunochemistry</topic><topic>Immunohistochemistry</topic><topic>Medical screening</topic><topic>Methodology</topic><topic>Middle Aged</topic><topic>Mismatch Repair Endonuclease PMS2</topic><topic>Mutation</topic><topic>MutL Protein Homolog 1</topic><topic>Nuclear Proteins - 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Academic</collection><jtitle>New Zealand medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Regan, Toni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunochemistry screening for Lynch syndrome in colorectal adenocarcinoma using an initial two antibody panel can replace a four antibody panel</atitle><jtitle>New Zealand medical journal</jtitle><addtitle>N Z Med J</addtitle><date>2013-09-13</date><risdate>2013</risdate><volume>126</volume><issue>1382</issue><spage>70</spage><epage>77</epage><pages>70-77</pages><issn>0028-8446</issn><issn>1175-8716</issn><eissn>1175-8716</eissn><abstract>Tests the hypothesis that staining for PMS2 and MSH6 antibodies alone will be sufficient to detect all cases of Lynch syndrome (LS) - also known as hereditary non polyposis colorectal cancer (HNPCC), an inherited autosomal dominant condition predisposing to early onset colorectal adenocarcinoma - and that it could replace routine screening with all four antibodies (MLH1, MSH2, MSH6, PMS2) which is current standard practice in immunochemistry staining for LS. 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| ispartof | New Zealand medical journal, 2013-09, Vol.126 (1382), p.70-77 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adenosine Triphosphatases - genetics Adenosine Triphosphatases - immunology Adult Aged Aged, 80 and over Cancer Cohort Studies Colon (Anatomy) Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - immunology Diagnosis Disease susceptibility DNA Repair Enzymes - genetics DNA Repair Enzymes - immunology DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Genes Genetic aspects Humans Immunochemistry Immunohistochemistry Medical screening Methodology Middle Aged Mismatch Repair Endonuclease PMS2 Mutation MutL Protein Homolog 1 Nuclear Proteins - genetics Nuclear Proteins - immunology Proteins Rectum Retrospective Studies Stains and staining (Microscopy) Young Adult |
| title | Immunochemistry screening for Lynch syndrome in colorectal adenocarcinoma using an initial two antibody panel can replace a four antibody panel |
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