Antimycobacterial Labdane Diterpenes from Leucas stelligera

Phytochemical investigation of the acetone extract of the aerial parts of Leucas stelligera afforded four new compounds (1–4) belonging to the labdane diterpene series as well as two known flavones, velutin (5) and chrysoeriol (6). Structure elucidation of the new compounds was carried out using 1D...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2013-10, Vol.76 (10), p.1836-1841
Hauptverfasser:	Kulkarni, Roshan R, Shurpali, Ketaki, Puranik, Vedavati G, Sarkar, Dhiman, Joshi, Swati P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - chemistry Antitubercular Agents - isolation & purification Antitubercular Agents - pharmacology Crystallography, X-Ray Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drug Screening Assays, Antitumor Flavones - chemistry Flavones - isolation & purification Hep G2 Cells Humans India Inhibitory Concentration 50 Lamiaceae - chemistry Microbial Sensitivity Tests Molecular Conformation Molecular Structure Mycobacterium tuberculosis - drug effects Nuclear Magnetic Resonance, Biomolecular
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Zusammenfassung:	Phytochemical investigation of the acetone extract of the aerial parts of Leucas stelligera afforded four new compounds (1–4) belonging to the labdane diterpene series as well as two known flavones, velutin (5) and chrysoeriol (6). Structure elucidation of the new compounds was carried out using 1D and 2D NMR spectroscopic data and single-crystal X-ray crystallography of compound 1. Compounds 1–4 exhibited selective antimycobacterial activity against Mycobacterium tuberculosis with IC50 values in the range 5.02–9.80 μg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np400002p