Glutathione and glutathione peroxidase expression in breast cancer: An immunohistochemical and molecular study

The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression...

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Veröffentlicht in:	Oncology reports 2013-09, Vol.30 (3), p.1119-1128
Hauptverfasser:	JARDIM, BRUNA VICTORASSO, MOSCHETTA, MARINA GOBBE, LEONEL, CAMILA, GELALETI, GABRIELA BOTTARO, REGIANI, VITOR RAFAEL, FERREIRA, LÍVIA CARVALHO, LOPES, JULIANA RAMOS, DE CAMPOS ZUCCARI, DEBORA AP. PIRES
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibiotics, Antineoplastic - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antioxidants Apoptosis - drug effects Blotting, Western Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Cell growth Cell Proliferation - drug effects Chemotherapy Chemotherapy, Adjuvant Cytotoxicity Doxorubicin - pharmacology Enzymes Epidermal growth factor Estrogens Female Follow-Up Studies glutathione Glutathione - metabolism Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Humans Immunoenzyme Techniques Immunohistochemistry Medical prognosis Metastasis Middle Aged Neoplasm Staging Patients Prognosis Radiation therapy real-time PCR Real-Time Polymerase Chain Reaction Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Rodents Survival Rate Tumor Cells, Cultured Tumors Womens health
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Zusammenfassung:	The use of prognostic markers for breast cancer allows therapeutic strategies to be defined more efficiently. The expression of glutathione (GSH) and glutathione peroxidase (GPX) in tumor cells has been evaluated as a predictor of prognosis and response to cytotoxic treatments. Its immunoexpression was assessed in 63 women diagnosed with invasive ductal carcinoma in a retrospective study. The results showed that high GSH expression was associated with tumors negative for the estrogen receptor (ER) (P
ISSN:	1021-335X 1791-2431
DOI:	10.3892/or.2013.2540