Metabolic Phenotyping of Diabetic Nephropathy

Diabetic nephropathy is the most serious complication of type 1 diabetes. There is no treatment to protect the kidneys from poorly controlled diabetes, and therefore prevention of the initial metabolic insults is currently the only effective approach to reducing the high mortality related to diabeti...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2013-11, Vol.94 (5), p.566-569
Hauptverfasser:	Mäkinen, V-P, Kangas, A J, Soininen, P, Würtz, P, Groop, P-H, Ala-Korpela, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Associated diseases and complications Biological and medical sciences Biomarkers - blood Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - metabolism Diabetes. Impaired glucose tolerance Diabetic Nephropathies - blood Diabetic Nephropathies - metabolism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Humans Kidneys Magnetic Resonance Spectroscopy Medical sciences Nephrology. Urinary tract diseases Pharmacology. Drug treatments Phenotype Risk Assessment Urinary system involvement in other diseases. Miscellaneous
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Zusammenfassung:	Diabetic nephropathy is the most serious complication of type 1 diabetes. There is no treatment to protect the kidneys from poorly controlled diabetes, and therefore prevention of the initial metabolic insults is currently the only effective approach to reducing the high mortality related to diabetic nephropathy. Metabolic phenotyping brings us one step closer to understanding the unique set of regulatory perturbations that predispose to kidney injury and paves the way for multiparametric risk assessment. Clinical Pharmacology & Therapeutics (2013); 94 5, 566–569. doi:10.1038/clpt.2013.158
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2013.158