Mechanisms of Napelline Action Stimulating the Regeneration of Hemopoietic Tissue in Cytostatic Myelosuppression

Pronounced regenerative effects of alkaloid napelline extracted from Aconitum baicalense on granulocytic hemopoiesis were revealed in the model of cytostatic myelosuppression. Activation of functions of hemopoietic progenitor cells along with increased feeder capacity of the stromal elements in the...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-08, Vol.155 (4), p.439-442
Hauptverfasser:	Zyuz’kov, G. N., Zhdanov, V. V., Udut, E. V., Miroshnichenko, L. A., Losev, E. A., Simanina, E. V., Chaikovskiy, A. V., Suslov, N. I., Povet’eva, T. N., Krapivin, A. V., Nesterova, Yu. V., Agafonov, V. I., Minakova, M. Yu, Stavrova, L. A., Danilets, M. G., Ligacheva, A. A., Trofimova, E. S., Ivanova, A. N., Goldberg, V. E., Reikchart, D. V., Dygai, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitine - pharmacology Animals Biomedical and Life Sciences Biomedicine Bone Marrow - drug effects Bone Marrow Cells - drug effects Bone Marrow Cells - physiology Cell Biology Cells, Cultured Cytostatic Agents - pharmacology Fluorouracil - pharmacology Hematopoiesis - drug effects Internal Medicine Laboratory Medicine Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mice, Inbred CBA Myeloid Progenitor Cells - drug effects Myeloid Progenitor Cells - physiology Pathology Physiological aspects Regenerative Medicine Stem cells
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Zusammenfassung:	Pronounced regenerative effects of alkaloid napelline extracted from Aconitum baicalense on granulocytic hemopoiesis were revealed in the model of cytostatic myelosuppression. Activation of functions of hemopoietic progenitor cells along with increased feeder capacity of the stromal elements in the hemopoiesis inducing microenvironment with decreased levels mesenchymal progenitor cells in the bone marrow are the mechanisms underlying the hemostimulating action of this substance.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-2172-7