Significance of INHBA expression in human colorectal cancer

Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC...

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Veröffentlicht in:	Oncology reports 2013-12, Vol.30 (6), p.2903-2908
Hauptverfasser:	OKANO, MIHO, YAMAMOTO, HIROFUMI, OHKUMA, HISATAKA, KANO, YOSHIHIRO, KIM, HIROTOSHI, NISHIKAWA, SHIMPEI, KONNO, MASAMITSU, KAWAMOTO, KOICHI, HARAGUCHI, NAOTSUGU, TAKEMASA, ICHIRO, MIZUSHIMA, TSUNEKAZU, IKEDA, MASATAKA, YOKOBORI, TAKEHIKO, MIMORI, KOSHI, SEKIMOTO, MITSUGU, DOKI, YUICHIRO, MORI, MASAKI, ISHII, HIDESHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigens Biomarkers, Tumor - genetics Cancer therapies Carcinogenesis - genetics Cell culture Cell Line, Tumor Cell Proliferation Chemotherapy Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Confidence intervals Dehydrogenases Female Gender Gene Expression Regulation, Neoplastic Humans inhibin β A Inhibin-beta Subunits - biosynthesis Inhibin-beta Subunits - genetics Lymphatic Metastasis - genetics Lymphatic Metastasis - pathology Lymphatic system Male Medical prognosis Metastasis Middle Aged Neoplasm Staging Prognosis Stem cells
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Zusammenfassung:	Inhibin β A (INHBA) is a member of the transforming growth factor β (TGF-β) superfamily. INHBA expression is associated with several types of human cancers; however, its significance in colorectal cancer (CRC) is not fully understood. INHBA expression was studied in 126 primary CRC samples and 4 CRC cell lines. Cell growth was assessed after inhibition of INHBA expression or after exogenous overexpression of INHBA in CRC tissues. INHBA expression was significantly higher in CRC tissues when compared to that in the corresponding normal tissues (P
ISSN:	1021-335X 1791-2431
DOI:	10.3892/or.2013.2761