Somatic and psychological effects of low-dose aromatase inhibition in men with obesity-related hypogonadotropic hypotestosteronemia

IntroductionReduced testosterone levels are frequently observed in obese men. Increased aromatase activity may be an etiological factor.ObjectiveIn this study, we evaluate the clinical effects of aromatase inhibition in obesity-related hypogonadotropic hypotestosteronemia (OrHH).MethodsDouble-blind,...

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Veröffentlicht in:	European journal of endocrinology 2013-11, Vol.169 (5), p.705-714
Hauptverfasser:	Loves, Sandra, de Jong, Jos, van Sorge, Adriaan, Telting, Darryl, Tack, Cees J, Hermus, Ad, Westerterp, Klaas, de Boer, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Androgens - blood Aromatase Inhibitors - administration & dosage Aromatase Inhibitors - adverse effects Aromatase Inhibitors - therapeutic use Biological and medical sciences Blood Glucose - metabolism Body Composition - drug effects Body Mass Index Bone Density - drug effects Clinical Study Double-Blind Method Endocrinopathies Energy Intake Estradiol - blood Exercise Tolerance - drug effects Exercise Tolerance - physiology Fundamental and applied biological sciences. Psychology Hormones - blood Humans Hypogonadism - blood Hypogonadism - complications Hypogonadism - psychology Lipid Metabolism - drug effects Luteinizing Hormone - blood Male Medical sciences Metabolic diseases Middle Aged Neuropsychological Tests Nitriles - administration & dosage Nitriles - adverse effects Nitriles - therapeutic use Obesity Obesity, Morbid - blood Obesity, Morbid - complications Obesity, Morbid - psychology Psychometrics Testosterone - blood Testosterone - deficiency Triazoles - administration & dosage Triazoles - adverse effects Triazoles - therapeutic use Vertebrates: endocrinology
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Zusammenfassung:	IntroductionReduced testosterone levels are frequently observed in obese men. Increased aromatase activity may be an etiological factor.ObjectiveIn this study, we evaluate the clinical effects of aromatase inhibition in obesity-related hypogonadotropic hypotestosteronemia (OrHH).MethodsDouble-blind, placebo-controlled, 6-month trial in 42 obese men with a BMI >35 kg/m2, and a serum total testosterone
ISSN:	0804-4643 1479-683X
DOI:	10.1530/EJE-13-0190