Developmental and hypoxia-induced cell death share common ultrastructural and biochemical apoptotic features in the central nervous system

Highlights • Ultrastructural features of HxCD during development are indistinguishable from those of NOCD. • The apoptotic intrinsic pathway is activated in hypoxic and developmental cell death. • Retinal afferent fibers do not regulate OT neuronal death on ED12. • The degeneration of neuronal proce...

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Veröffentlicht in:	Neuroscience 2013-11, Vol.252, p.190-200
Hauptverfasser:	Pozo Devoto, V.M, Bogetti, M.E, Fiszer de Plazas, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - physiology Biological and medical sciences Blotting, Western Chick Embryo chick optic tectum Chickens development Eye and associated structures. Visual pathways and centers. Vision Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology hypoxia Hypoxia - pathology In Situ Nick-End Labeling Microscopy, Electron, Transmission Neurology neuronal death Superior Colliculi - embryology Superior Colliculi - metabolism Superior Colliculi - pathology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Ultrastructural features of HxCD during development are indistinguishable from those of NOCD. • The apoptotic intrinsic pathway is activated in hypoxic and developmental cell death. • Retinal afferent fibers do not regulate OT neuronal death on ED12. • The degeneration of neuronal processes has unique ultrastructural features.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.07.065