Blockade of the dorsal hippocampal dopamine D1 receptors inhibits the scopolamine-induced state-dependent learning in rats

Highlights • Scopolamine-induced state-dependent learning. • Intra-CA1 injection of SKF38393 reversed the amnesia induced by scopolamine. • Intra-CA1 injection of SCH23390 inhibited scopolamine state-dependent memory. • Ineffective dose of scopolamine blocked improving effect of SKF38393 on memory....

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Veröffentlicht in:	Neuroscience 2013-11, Vol.252, p.460-467
Hauptverfasser:	Piri, M, Rostampour, M, Nasehi, M, Zarrindast, M.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amnesia - chemically induced Animals Biological and medical sciences CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - metabolism Cholinergic Antagonists - administration & dosage Dopamine Agonists - administration & dosage Dopamine Antagonists - administration & dosage dopamine D1 receptors dorsal hippocampus Fundamental and applied biological sciences. Psychology inhibitory avoidance memory Injections, Intraventricular Learning - drug effects Learning - physiology Male Memory - physiology Microinjections Neurology rat Rats Rats, Wistar Receptors, Dopamine D1 - metabolism scopolamine Scopolamine Hydrobromide - administration & dosage state-dependent memory Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Scopolamine-induced state-dependent learning. • Intra-CA1 injection of SKF38393 reversed the amnesia induced by scopolamine. • Intra-CA1 injection of SCH23390 inhibited scopolamine state-dependent memory. • Ineffective dose of scopolamine blocked improving effect of SKF38393 on memory. • SCH23390 prevented improving effect of SKF38393 on scopolamine amnesia.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.08.003