Enhanced visual responses in the superior colliculus and subthalamic nucleus in an animal model of Parkinson’s disease

Highlights • Superior colliculus is functionally altered in a rat model of Parkinson’s disease. • This structure may undergo neuroplastic changes following a dopaminergic lesion. • It shows increased sensitivity to the presentation of light flashes. • Those facilitated light responses are then trans...

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Veröffentlicht in:	Neuroscience 2013-11, Vol.252, p.277-288
Hauptverfasser:	Rolland, M, Carcenac, C, Overton, P.G, Savasta, M, Coizet, V
Format:	Artikel
Sprache:	eng
Schlagworte:	6-OHDA lesion Adaptation, Physiological - physiology Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Electrophysiological Phenomena Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Medical sciences Neurology Parkinsonian Disorders - physiopathology Parkinson’s disease Rats Rats, Long-Evans substantia nigra pars compacta subthalamic nucleus Subthalamic Nucleus - physiopathology Superior Colliculi - physiopathology superior colliculus Vertebrates: nervous system and sense organs Visual Perception - physiology
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Zusammenfassung:	Highlights • Superior colliculus is functionally altered in a rat model of Parkinson’s disease. • This structure may undergo neuroplastic changes following a dopaminergic lesion. • It shows increased sensitivity to the presentation of light flashes. • Those facilitated light responses are then transmitted to the subthalamic nucleus. • Light responses in the subthalamic nucleus are also increased in lesioned rats.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.07.047