Mechanisms of Hemostimulating Effect of Aconitum baicalense Diterpene Alkaloids

A mixture of diterpene alkaloids of Aconitum baicalense exhibited pronounced regenerative hemostimulating properties on the model of cytostatic myelosuppression. The therapeutic effect is based on activation of hemopoietic progenitor cells against the background of increased feeder capacity of strom...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2013-07, Vol.155 (3), p.350-353
Hauptverfasser:	Zyuz’kov, G. N., Zhdanov, V. V., Miroshnichenko, L. A., Udut, E. V., Simanina, E. V., Stavrova, L. A., Agafonov, V. I., Chaikovskiy, A. V., Minakova, M. Yu, Povet’eva, T. N., Suslov, N. I., Krapivin, A. V., Nesterova, Yu. V., Semenov, A. A., Reykhart, D. V., Dygai, A. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitum - chemistry Alkaloids Alkaloids - analysis Alkaloids - pharmacology Animals Biomedical and Life Sciences Biomedicine Bone Marrow Cells - drug effects Cell Biology Cellular Microenvironment Diterpenes - analysis Diterpenes - pharmacology Fluorouracil Hematopoiesis - drug effects Hematopoietic Stem Cells - drug effects Internal Medicine Laboratory Medicine Mice Pathology Regenerative Medicine - methods Stem cells
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Zusammenfassung:	A mixture of diterpene alkaloids of Aconitum baicalense exhibited pronounced regenerative hemostimulating properties on the model of cytostatic myelosuppression. The therapeutic effect is based on activation of hemopoietic progenitor cells against the background of increased feeder capacity of stromal compartment of the hemopoiesis-inducing microenvironment and decreased count of mesenchymal stem cells in the bone marrow.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-013-2151-z