Recent advances in biosensor based endotoxin detection

Endotoxins also referred to as pyrogens are chemically lipopolysaccharides habitually found in food, environment and clinical products of bacterial origin and are unavoidable ubiquitous microbiological contaminants. Pernicious issues of its contamination result in high mortality and severe morbidities. Standard traditional techniques are slow and cumbersome, highlighting the pressing need for evoking agile endotoxin detection system. The early and prompt detection of endotoxin assumes prime importance in health care, pharmacological and biomedical sectors. The unparalleled recognition abilities of LAL biosensors perched with remarkable sensitivity, high stability and reproducibility have bestowed it with persistent reliability and their possible fabrication for commercial applicability. This review paper entails an overview of various trends in current techniques available and other possible alternatives in biosensor based endotoxin detection together with its classification, epidemiological aspects, thrust areas demanding endotoxin control, commercially available detection sensors and a revolutionary unprecedented approach narrating the influence of omics for endotoxin detection. •The sensing efficiency of various endotoxin based biosensors has been compared.•Graphical illustrations of working mechanism for possible biosensor are provided.•A detailed study on the commercially available biosensor kits has been reviewed.•Special focus has been given on OMICS (rFC) approach for endotoxin detection.•Lab-on-a-chip, printed biosensors and LOCAD-PTS have been briefly discussed.