Elevation of Plasma Milrinone Concentrations in Stage D Heart Failure Associated With Renal Dysfunction
Purpose: To determine steady state milrinone concentrations in patients with stage D heart failure (HF) with and without renal dysfunction Methods: We retrospectively identified patients with stage D HF at a single medical center on continuous milrinone infusion at the time of plasma collection for...
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Veröffentlicht in: | Journal of cardiovascular pharmacology and therapeutics 2013-09, Vol.18 (5), p.433-438 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Purpose:
To determine steady state milrinone concentrations in patients with stage D heart failure (HF) with and without renal dysfunction
Methods:
We retrospectively identified patients with stage D HF at a single medical center on continuous milrinone infusion at the time of plasma collection for entry into a research registry database. Milrinone was prescribed and titrated to improve hemodynamic and clinical status by a cardiologist. Plasma samples were obtained at steady state milrinone concentrations. Patients were stratified by creatinine clearance (CrCl) into 4 groups: group 1 (CrCl >60 mL/min), group 2 (CrCl 60-30 mL/min), group 3 (CrCl |
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ISSN: | 1074-2484 1940-4034 |
DOI: | 10.1177/1074248413489773 |