Efficient Synthesis and Antioxidant Evaluation of 2-Aryl-3-(Pyrimidin-2-yl)-Thiazolidinones

Efficient Synthesis and Antioxidant Evaluation of 2-Aryl-3-(Pyrimidin-2-yl)-Thiazolidinones

ABSTRACT In the present study, we reported the efficient synthesis of 11 3‐(pyrimidin‐2‐yl)‐thiazolidinones in good yields using molecular sieve as the desiccant agent. In addition, we have evaluated the antioxidant capacity of the synthesized compounds by the 2,2‐diphenyl‐2‐picrylhydrazyl hydrate (...

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Veröffentlicht in:Journal of biochemical and molecular toxicology 2013-09, Vol.27 (9), p.445-450
Hauptverfasser: Campos Júnior, José C., Gouvêa, Daniela P., Ribeiro, Camila da S., Dutra, Filipe S. P., Stefanello, Francieli M., Pereira, Claudio M. P., Cunico, Wilson, Siqueira, Geonir M.
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidant Activity
Antioxidants - chemical synthesis
Antioxidants - chemistry
Benzothiazoles - chemistry
Free Radical Scavengers - chemistry
Molecular Sieves
Oxidation-Reduction
Pyrimidines - chemistry
Sulfonic Acids - chemistry
Thiazolidines - chemical synthesis
Thiazolidines - chemistry
Thiazolidinones
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Zusammenfassung:ABSTRACT In the present study, we reported the efficient synthesis of 11 3‐(pyrimidin‐2‐yl)‐thiazolidinones in good yields using molecular sieve as the desiccant agent. In addition, we have evaluated the antioxidant capacity of the synthesized compounds by the 2,2‐diphenyl‐2‐picrylhydrazyl hydrate (DPPH•) and the 2,2‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) diammonium salt (ABTS+•) radicals scavenging assay. Six compounds showed antioxidant activity towards DPPH• (EC50 between 16.13 and 49.94 µg/mL) and also demonstrated excellent activity regarding ABTS+• (TEAC: 10.32–53.52). These results showed that compounds 3‐(pyrimidin‐2‐yl)‐thiazolidinones may be easily synthesized by a less expensive procedure and could be a good starting point to the development of new antioxidant compounds. © 2013 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:445‐450, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21506
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.21506