Pharmacokinetics of linezolid in the mediastinum and pleural space

Summary The purpose of this study was to investigate the penetration of linezolid into the mediastinum and pleural space by comparing its concentration in the serum, mediastinum, and pleural space. The linezolid area under the concentration-versus-time curve from zero to 12 h (AUC)mediastinumfluid/s...

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Veröffentlicht in:	International journal of infectious diseases 2013-11, Vol.17 (11), p.e1060-e1061
Hauptverfasser:	Tsuji, Yasuhiro, Hashimoto, Wataru, Taniguchi, Shinichiro, Hiraki, Yoichi, Mizoguchi, Akiko, Yukawa, Eiji, To, Hideto
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacokinetics Anti-Infective Agents - pharmacokinetics Cardiovascular surgery Extracellular Fluid - metabolism Humans Infectious Disease Linezolid Male Mediastinitis Mediastinitis - diagnosis Mediastinitis - metabolism Mediastinitis - microbiology Mediastinum Oxazolidinones - pharmacokinetics Penetration to mediastinum Permeability Pharmacokinetics Pleural Cavity - metabolism Pleural Effusion - metabolism Pulmonary/Respiratory
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Zusammenfassung:	Summary The purpose of this study was to investigate the penetration of linezolid into the mediastinum and pleural space by comparing its concentration in the serum, mediastinum, and pleural space. The linezolid area under the concentration-versus-time curve from zero to 12 h (AUC)mediastinumfluid/serum and AUCpleuralfluid/serum ratio were 1.32 and 1.64, respectively. The results suggest that the linezolid concentration in the mediastinum varies as in the serum, and that the concentration in the mediastinum is the same as or greater than that in the serum.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2013.03.008