Brinzolamide-timolol fixed combination for the prevention of intraocular pressure elevation after phacoemulsification

Background To evaluate the efficacy of brinzolamide‐timolol fixed combination in intraocular pressure during the first 24 h after uneventful phacoemulsification cataract surgery using Viscoat and Provisc. Design Prospective randomized comparative case series. Participants Ninety‐two eyes of equal patients scheduled for phacoemulsification cataract surgery. Methods Treatment group (52 eyes) received a drop of brinzolamide‐timolol fixed combination immediately after surgery. Control group (40 eyes) received no treatment. Main Outcome Measures Intraocular pressure preoperatively and at 6, 12 and 24 h postoperatively. Results Six hours after surgery the mean intraocular pressure decreased by 0.3 ± 2.95 mmHg (P > 0.05) in the treatment group and increased by 6.8 ± 2.78 mmHg (P 0.05) in the treatment group and by 5.3 ± 3.26 mmHg (P