Circulating chemokine (C‐X‐C Motif) receptor 5+CD4+ T cells benefit hepatitis B e antigen seroconversion through IL‐21 in patients with chronic hepatitis B virus infection

Given the clinical significance of hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B virus (HBV) infection, it is critical to elucidate the mechanisms regulating this process. In the present study, we found that the frequency of circulating chemokine (C‐X‐C motif) receptor 5 (CXCR5...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2013-10, Vol.58 (4), p.1277-1286
Hauptverfasser:	Li, Yongyin, Ma, Shiwu, Tang, Libo, Li, Yun, Wang, Wei, Huang, Xuan, Lai, Qintao, Zhang, Mingxia, Sun, Jian, Li, Chris Kafai, Abbott, William G.H., Naoumov, Nikolai V., Zhang, Yu, Hou, Jinlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Viral - blood Antiviral Agents - therapeutic use Biomarkers - blood CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology Cells, Cultured Chemokines Cross-Sectional Studies Female Hepatitis Hepatitis B Hepatitis B e Antigens - blood Hepatitis B virus - immunology Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - immunology Hepatitis B, Chronic - metabolism Hepatology Humans In Vitro Techniques Infections Interferon Interleukins - metabolism Interleukins - pharmacology Longitudinal Studies Lymphocytes Male Middle Aged Phenotype Receptors, CXCR5 - metabolism Recombinant Proteins - pharmacology Thymidine - analogs & derivatives Thymidine - therapeutic use Young Adult
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Zusammenfassung:	Given the clinical significance of hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B virus (HBV) infection, it is critical to elucidate the mechanisms regulating this process. In the present study, we found that the frequency of circulating chemokine (C‐X‐C motif) receptor 5 (CXCR5)+CD4+ T cells was higher in patients who had achieved HBeAg seroconversion in both cross‐sectional (P
ISSN:	0270-9139 1527-3350
DOI:	10.1002/hep.26489