C. elegans for anti-infective discovery

Highlights • The model host C. elegans is becoming more popular in infectious disease research. • It is broadly used as an in vivo screening model for new antimicrobial agents. • It can also identify compounds that affect virulence or alter the immune response. • It is also used to test compound tox...

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Veröffentlicht in:	Current opinion in pharmacology 2013-10, Vol.13 (5), p.769-774
Hauptverfasser:	Arvanitis, Marios, Glavis-Bloom, Justin, Mylonakis, Eleftherios
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents Caenorhabditis elegans Disease Models, Animal Drug Discovery High-Throughput Screening Assays Internal Medicine Medical Education
Online-Zugang:	Volltext
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Zusammenfassung:	Highlights • The model host C. elegans is becoming more popular in infectious disease research. • It is broadly used as an in vivo screening model for new antimicrobial agents. • It can also identify compounds that affect virulence or alter the immune response. • It is also used to test compound toxicity and discover antihelminthic agents. • Its main advantage is its amenability for high-throughput screens.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2013.08.002