Preventive effects of polysaccharides from Liriope spicata var. prolifera on diabetic nephropathy in rats

This study was undertaken to investigate preventive effects of polysaccharides (LSP) from Liriope spicata var. prolifera on diabetic nephropathy in rats, which were induced by high fat-fed and low-dose streptozotocin (STZ). The levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c...

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Veröffentlicht in:	International journal of biological macromolecules 2013-10, Vol.61, p.114-120
Hauptverfasser:	Xiao, Zuo-qi, Wang, Yong-long, Yue, Yao-dong, Zhang, Yu-tang, Chen, Cui-ping, Wan, Luo-sheng, Deng, Bin, Liu, Zhao-xia, Chen, Jia-chun
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced glycation end products animal disease models Animals Antioxidants - metabolism Blood Glucose Carbohydrates - chemistry Diabetes Mellitus, Experimental Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic nephropathy fasting Fasting - blood glucose tolerance Glucose Tolerance Test Glycated Hemoglobin A - metabolism Glycation End Products, Advanced - metabolism glycosylation hemoglobin Hyperglycemic hyperlipidemia Insulin - blood Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney - physiopathology kidneys Lipids - blood Liriope Plant - chemistry Liriope spicata Liriope spicata var. prolifera Male Molecular Weight Monosaccharides - chemistry oxidative stress Plant Extracts - chemistry Plant Extracts - pharmacology Polysaccharide polysaccharides Polysaccharides - chemistry Polysaccharides - pharmacology Rats Receptor for Advanced Glycation End Products Receptors, Immunologic - metabolism renal function streptozotocin
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Zusammenfassung:	This study was undertaken to investigate preventive effects of polysaccharides (LSP) from Liriope spicata var. prolifera on diabetic nephropathy in rats, which were induced by high fat-fed and low-dose streptozotocin (STZ). The levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in diabetic rats were significantly decreased after treated with LSP for 28 days. Additional, the glucose tolerance of diabetes rats showed improvement after administration of LSP. The results also indicated that LSP were able to normalize hyperlipidemia, ameliorate oxidative stress, improve renal function parameters, inhibit the structural damages of kidney tissue and down-regulate the system of advanced glycation end products – receptor for advanced glycation end products (AGE-RAGE). In conclusion, LSP had potential preventive effects on diabetic nephropathy in diabetic rats.
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2013.06.047