Kinetics of maternally acquired anti-hepatitis A antibodies: Prediction of waning based on maternal or cord blood antibody levels

Highlights ► Maternal anti-hepatitis A antibodies impede the immune response to hepatitis A vaccines in infants. ► We found a transplacental transport of maternal anti-hepatitis A antibodies a ratio of approx. 1.0. ► Serum half-life of maternal, infection-induced anti-hepatitis A antibodies is shown...

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Veröffentlicht in:Vaccine 2013-03, Vol.31 (11), p.1490-1495
Hauptverfasser: Brinkhof, Martin W.G, Mayorga, Orlando, Bock, Jürgen, Heininger, Ulrich, Herzog, Christian
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container_end_page 1495
container_issue 11
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container_title Vaccine
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creator Brinkhof, Martin W.G
Mayorga, Orlando
Bock, Jürgen
Heininger, Ulrich
Herzog, Christian
description Highlights ► Maternal anti-hepatitis A antibodies impede the immune response to hepatitis A vaccines in infants. ► We found a transplacental transport of maternal anti-hepatitis A antibodies a ratio of approx. 1.0. ► Serum half-life of maternal, infection-induced anti-hepatitis A antibodies is shown to be 40 days. ► We present a formula estimating from maternal or cord blood antibody levels time until full waning.
doi_str_mv 10.1016/j.vaccine.2013.01.011
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source MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland
subjects Adolescent
Adult
Age
Allergy and Immunology
antibodies
Applied microbiology
Babies
Biological and medical sciences
Blood
childhood
Children & youth
enzyme immunoassays
Female
Fetal Blood - immunology
Fundamental and applied biological sciences. Psychology
half life
Hepatitis
Hepatitis A
Hepatitis A Antibodies - blood
Hepatitis A virus
Hepatitis A virus - immunology
Human viral diseases
Humans
Immune response
Immunity, Maternally-Acquired
Immunization
Immunoenzyme Techniques
immunoglobulin G
Immunoglobulin G - blood
Infant
Infant, Newborn
Infants
Infectious diseases
Longitudinal Studies
Male
Maternal antibodies
maternal immunity
Medical sciences
Medical treatment
Microbiology
Mothers
neonates
Newborn babies
Nicaragua
Pediatrics
Placental transfer
Population
prediction
Pregnancy
seroprevalence
Shipments
Studies
Time Factors
vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral hepatitis
Waning immunity
Young Adult
title Kinetics of maternally acquired anti-hepatitis A antibodies: Prediction of waning based on maternal or cord blood antibody levels
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