Kinetics of maternally acquired anti-hepatitis A antibodies: Prediction of waning based on maternal or cord blood antibody levels

Highlights ► Maternal anti-hepatitis A antibodies impede the immune response to hepatitis A vaccines in infants. ► We found a transplacental transport of maternal anti-hepatitis A antibodies a ratio of approx. 1.0. ► Serum half-life of maternal, infection-induced anti-hepatitis A antibodies is shown...

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Veröffentlicht in:	Vaccine 2013-03, Vol.31 (11), p.1490-1495
Hauptverfasser:	Brinkhof, Martin W.G, Mayorga, Orlando, Bock, Jürgen, Heininger, Ulrich, Herzog, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Allergy and Immunology antibodies Applied microbiology Babies Biological and medical sciences Blood childhood Children & youth enzyme immunoassays Female Fetal Blood - immunology Fundamental and applied biological sciences. Psychology half life Hepatitis Hepatitis A Hepatitis A Antibodies - blood Hepatitis A virus Hepatitis A virus - immunology Human viral diseases Humans Immune response Immunity, Maternally-Acquired Immunization Immunoenzyme Techniques immunoglobulin G Immunoglobulin G - blood Infant Infant, Newborn Infants Infectious diseases Longitudinal Studies Male Maternal antibodies maternal immunity Medical sciences Medical treatment Microbiology Mothers neonates Newborn babies Nicaragua Pediatrics Placental transfer Population prediction Pregnancy seroprevalence Shipments Studies Time Factors vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral hepatitis Waning immunity Young Adult
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Beschreibung
Zusammenfassung:	Highlights ► Maternal anti-hepatitis A antibodies impede the immune response to hepatitis A vaccines in infants. ► We found a transplacental transport of maternal anti-hepatitis A antibodies a ratio of approx. 1.0. ► Serum half-life of maternal, infection-induced anti-hepatitis A antibodies is shown to be 40 days. ► We present a formula estimating from maternal or cord blood antibody levels time until full waning.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.01.011