An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine

Highlights • Ad5-A24 plus Ad5-LTR72 induced serum neutralizing antibodies against FMDV. • Ad5-A24 plus Ad5-LTR72 had the highest IgM and IgG production in blood. • Ad5-A24 plus Ad5-LTR72 induced both systemic and mucosal immune responses. • Ad5-A24 plus Ad5-LTR72 resulted in 100% survival and the co...

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Veröffentlicht in:	Vaccine 2013-04, Vol.31 (18), p.2302-2309
Hauptverfasser:	Alejo, Diana M, Moraes, Mauro P, Liao, Xiaofen, Dias, Camila C, Tulman, Edan R, Segundo, Fayna Diaz-San, Rood, Debra, Grubman, Marvin J, Silbart, Lawrence K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenoviruses Adjuvants Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Administration, Intranasal Allergy and Immunology Animals antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Applied microbiology Bacterial Toxins - administration & dosage Bacterial Toxins - immunology Biological and medical sciences Cattle Cell Line Cloning Cytomegalovirus E. coli enterotoxin Enterotoxins - administration & dosage Enterotoxins - immunology Escherichia coli - chemistry Escherichia coli Proteins - administration & dosage Escherichia coli Proteins - immunology Female FMDV Foot & mouth disease Foot-and-Mouth Disease - immunology Foot-and-Mouth Disease - prevention & control Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - immunology Fundamental and applied biological sciences. Psychology Genetic Vectors humoral immunity Immunity, Humoral Immunity, Mucosal Immunization Immunoglobulin G - blood Immunoglobulin M - blood Immunology Infections intranasal administration lethal dose Livestock livestock and meat industry Livestock industry Mice Mice, Inbred C57BL Microbiology Miscellaneous morbidity mucosa Mucosal immunity neutralization Pathogens Plasmids serotypes subunit vaccines Swine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - genetics Vaccines, Subunit - immunology Viral Vaccines - genetics Viral Vaccines - immunology Viremia - immunology Virology
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Zusammenfassung:	Highlights • Ad5-A24 plus Ad5-LTR72 induced serum neutralizing antibodies against FMDV. • Ad5-A24 plus Ad5-LTR72 had the highest IgM and IgG production in blood. • Ad5-A24 plus Ad5-LTR72 induced both systemic and mucosal immune responses. • Ad5-A24 plus Ad5-LTR72 resulted in 100% survival and the complete absence of viremia.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.02.060