Preventive and therapeutic DNA vaccination partially protect dogs against an infectious challenge with Trypanosoma cruzi

Highlights • We evaluated the safety and efficacy of a DNA vaccine against Trypanosoma cruzi in dogs. • Vaccination reduced parasitemia, cardiac inflammation and parasite burden. • Vaccination tended to decrease arrhythmias and mortality. • Vaccination may reduce parasite transmission and disease pr...

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Veröffentlicht in:	Vaccine 2013-04, Vol.31 (18), p.2246-2252
Hauptverfasser:	Quijano-Hernández, Israel A, Castro-Barcena, Alejandro, Vázquez-Chagoyán, Juan C, Bolio-González, Manuel E, Ortega-López, Jaime, Dumonteil, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology anemia Animal model Animals Antibodies, Protozoan - blood antigens Antigens, Protozoan - genetics Antigens, Protozoan - immunology Applied microbiology arrhythmia Biological and medical sciences blood composition Cardiopathy Chagas disease Chagas Disease - immunology Chagas Disease - prevention & control Chagas Disease - therapy disease control disease course DNA dog diseases Dogs Fundamental and applied biological sciences. Psychology Heart - parasitology Human protozoal diseases humans Immunization Infectious diseases inflammation Life cycle. Host-agent relationship. Pathogenesis Medical sciences mice Microbiology Parasite Load parasitemia Parasitemia - immunology Parasitemia - prevention & control Parasitemia - therapy parasites Parasitic diseases Protozoa Protozoal diseases Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Vaccines - genetics Protozoan Vaccines - immunology Protozoan Vaccines - therapeutic use recombinant vaccines Trypanosoma cruzi Trypanosomiasis vaccination Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - immunology Vaccines, DNA - therapeutic use
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Beschreibung
Zusammenfassung:	Highlights • We evaluated the safety and efficacy of a DNA vaccine against Trypanosoma cruzi in dogs. • Vaccination reduced parasitemia, cardiac inflammation and parasite burden. • Vaccination tended to decrease arrhythmias and mortality. • Vaccination may reduce parasite transmission and disease progression in dogs.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.03.005